Varadharaj Venkatesh, Petersen Wyatt, Batra Surinder K, Ponnusamy Moorthy P
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center at Omaha, NE, USA.
Trends Cell Biol. 2025 May;35(5):412-425. doi: 10.1016/j.tcb.2024.09.006. Epub 2024 Oct 26.
Glycosylation is a complex co-translational and post-translational modification (PTM) in eukaryotes that utilizes glycosyltransferases to generate a vast array of glycoconjugate structures. Recent studies have highlighted the role of glycans in regulating essential molecular, cellular, tissue, organ, and systemic biological processes with significant implications for human diseases, particularly cancer. The metabolic reliance of cancer, spanning tumor initiation, disease progression, and resistance to therapy, necessitates a range of uniquely altered cellular metabolic pathways. In addition, the intricate interplay between cell-intrinsic and -extrinsic mechanisms is exemplified by the communication between cancer cells, cancer stem cells (CSCs), cancer-associated fibroblasts (CAFs), and immune cells within the tumor microenvironment (TME). In this review article, we explore how differential glycosylation in cancer influences the metabolism and stemness features alongside new avenues in glycobiology.
糖基化是真核生物中一种复杂的共翻译和翻译后修饰（PTM），它利用糖基转移酶生成大量的糖缀合物结构。最近的研究强调了聚糖在调节基本分子、细胞、组织、器官和全身生物学过程中的作用，这对人类疾病，尤其是癌症具有重要意义。癌症在肿瘤发生、疾病进展和对治疗的耐药性方面的代谢依赖性，需要一系列独特改变的细胞代谢途径。此外，细胞内在和外在机制之间的复杂相互作用体现在肿瘤微环境（TME）中癌细胞、癌症干细胞（CSC）、癌症相关成纤维细胞（CAF）和免疫细胞之间的通讯上。在这篇综述文章中，我们探讨了癌症中的差异糖基化如何影响代谢和干性特征以及糖生物学的新途径。
