Van Cauwenberghe Jolijn, Van Dessel Kristof, De Block Christophe, Dirinck Eveline
Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Laboratory of Experimental Medicine and Paediatrics (LEMP), Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium.
Clin Endocrinol (Oxf). 2025 Jan;102(1):44-50. doi: 10.1111/cen.15157. Epub 2024 Oct 27.
Basal metabolic rate (BMR) is an important factor in weight management and is influenced by fat-free mass (FFM), fat mass (FM) and age. Current knowledge of the influence of hormonal levels on BMR is based on studies with small populations, studies that investigate exogenous administration and studies frequently lacking correction for body composition.
Cross-sectional study.
All men (n = 457) who were referred to our centre for a metabolic work-up were eligible for inclusion. Median age was 47 (18-78) years and the vast majority had obesity (BMI ≥ 30 kg/m², 90.9%).
All men had a measurement of BMR, body composition and measurement of testosterone, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone (TSH) and free thyroxine (fT4). Men with low, normal and/or high levels of each of these hormones were compared. The association between hormone levels and BMR was assessed through linear regression models. All analyses were controlled for FFM, FM and age.
In men with obesity, testosterone (total or free) was not associated with BMR. Linear regression analysis showed that DHEAS was positively associated with BMR in a sample of men with obesity and normal endogenous DHEAS levels, with the following equation: BMR (adjusted R² = 0.72): (BMR [kcal/d] = 513.402 + 18.940 × FFM [kg] + 9.507 × FM [kg] - 3.362 × age [years] + 0.307 × DHEAS [µg/dL]) (p < 0.01). TSH, fT4 and IGF-1 were not associated with BMR.
In men with obesity, endogenous DHEAS is positively associated with BMR. Testosterone, TSH, fT4 and IGF-1 were not associated with BMR in men with obesity. Since we examined the specific population of men with obesity and only examined endogenous hormone levels, no extrapolation of results to other populations or the overall population can be made.
基础代谢率（BMR）是体重管理中的一个重要因素，受去脂体重（FFM）、体脂量（FM）和年龄影响。目前关于激素水平对BMR影响的认识基于小样本研究、调查外源性给药的研究以及经常缺乏对身体成分校正的研究。
横断面研究。
所有转诊至我们中心进行代谢检查的男性（n = 457）均符合纳入条件。中位年龄为47（18 - 78）岁，绝大多数人患有肥胖症（BMI≥30 kg/m²，90.9%）。
所有男性均测量了BMR、身体成分，并测量了睾酮、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS）、胰岛素样生长因子1（IGF - 1）、促甲状腺激素（TSH）和游离甲状腺素（fT4）。对每种激素水平低、正常和/或高的男性进行了比较。通过线性回归模型评估激素水平与BMR之间的关联。所有分析均对FFM、FM和年龄进行了校正。
在肥胖男性中，睾酮（总睾酮或游离睾酮）与BMR无关。线性回归分析表明，在肥胖且内源性DHEAS水平正常的男性样本中，DHEAS与BMR呈正相关，具体方程如下：BMR（调整后R² = 0.72）：（BMR [千卡/天] = 513.402 + 18.940×FFM [千克] + 9.507×FM [千克] - 3.362×年龄 [岁] + 0.307×DHEAS [微克/分升]）（p < 0.01）。TSH、fT4和IGF - 1与BMR无关。
在肥胖男性中，内源性DHEAS与BMR呈正相关。睾酮、TSH、fT4和IGF - 1在肥胖男性中与BMR无关。由于我们研究的是肥胖男性这一特定人群，且仅检测了内源性激素水平，因此无法将结果外推至其他人群或总体人群。
