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《免疫球蛋白G4相关性眼病诊断和治疗专家共识(2024年版)》

[Expert consensus on the diagnosis and treatment of immunoglobulin-G4 related ophthalmic disease (2024 edition)].

出版信息

Zhonghua Yi Xue Za Zhi. 2024 Oct 29;104(40):3726-3735. doi: 10.3760/cma.j.cn112137-20240814-01870.

Abstract

Immunoglobulin-G4 related ophthalmic disease (IgG4-ROD) is an immune-mediated fibroin flammatory condition characterized by ocular mass lesions and elevated plasma IgG4 level. Since all the ocular tissues can be involved, and it can be accompanied by multiple organ and systemic diseases, the diagnosis and treatment require multidisciplinary collaboration. The Oculoplastic and Orbital Disease Group of Chinese Ophthalmological Society of Chinese Medical Association and the Chinese Rheumatology Association convened experts in ophthalmology, and rheumatology and immunology, and formulated "Expert consensus on the diagnosis and treatment of immunoglobulin-G4 related ophthalmic disease (2024 edition)" for the diagnosis and treatment of IgG4-ROD based on domestic and international studies and experience. The consensus mainly standardized the diagnostic criteria of IgG4-ROD from the aspects of ocular imaging, serum IgG4 level and ocular histopathology, and recommended the methods and indications of drug therapy (glucocorticoids, immunosuppressants and biologics) and surgical treatment.

摘要

免疫球蛋白G4相关性眼病(IgG4-ROD)是一种免疫介导的纤维炎性疾病,其特征为眼部肿块病变和血浆IgG4水平升高。由于所有眼组织均可受累,且可伴有多器官及全身性疾病,因此诊断和治疗需要多学科协作。中华医学会眼科学分会眼整形眼眶病学组与中华医学会风湿病学分会召集眼科、风湿免疫科专家,基于国内外研究及经验,制定了《免疫球蛋白G4相关性眼病诊断和治疗专家共识(2024年版)》,用于IgG4-ROD的诊断和治疗。该共识主要从眼部影像学、血清IgG4水平及眼部组织病理学等方面规范了IgG4-ROD的诊断标准,并推荐了药物治疗(糖皮质激素、免疫抑制剂及生物制剂)及手术治疗的方法和适应证。

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