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阳光维生素的阴暗面:一例因过量摄入维生素D导致的急性肾衰竭和高钙血症

The Dark Side of the Sunshine Vitamin: A Case of Acute Renal Failure and Hypercalcaemia From Vitamin D Overconsumption.

作者信息

Khan Sheharyar, Tariq Muhammad Wasim, Akhtar Muhammad, Raza Muhammad Tanseer Sibtain, Manzoor Muhammad

机构信息

Emergency Medicine, United Lincolnshire Hospitals National Health Service (NHS) Trust, Grantham and District Hospital, Grantham, GBR.

Endocrinology, United Lincolnshire Hospitals National Health Service (NHS) Trust, Pilgrim Hospital, Boston, GBR.

出版信息

Cureus. 2024 Sep 26;16(9):e70237. doi: 10.7759/cureus.70237. eCollection 2024 Sep.

Abstract

Vitamin D toxicity is a rare but potentially serious condition that can lead to severe hypercalcaemia and subsequent complications, such as acute renal failure, nephrocalcinosis, congestive heart failure and coronary calcium deposition, resulting in myocardial injury. We present a case of a 76-year-old male patient who developed severe hypercalcaemia and acute kidney injury due to excessive long-term over-the-counter vitamin D supplementation. The patient was initially treated with aggressive intravenous fluids and furosemide. However, a failed effective response prompted the addition of pamidronate, resulting in the gradual improvement of hypercalcaemia and renal function. We have presented, in this case, a rare adverse effect of vitamin D toxicity and its multiorgan effect.

摘要

维生素D中毒是一种罕见但可能严重的病症,可导致严重高钙血症及随后的并发症,如急性肾衰竭、肾钙质沉着、充血性心力衰竭和冠状动脉钙沉积,进而导致心肌损伤。我们报告一例76岁男性患者,因长期过量服用非处方维生素D补充剂而出现严重高钙血症和急性肾损伤。患者最初接受积极的静脉补液和呋塞米治疗。然而,因治疗效果不佳,加用了帕米膦酸盐,高钙血症和肾功能逐渐改善。我们在此病例中展示了维生素D中毒的罕见不良反应及其多器官影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bac/11512663/2a6a8952c4c4/cureus-0016-00000070237-i01.jpg

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