May Ingyin, Akunuri Srikanth
General Medicine, King's College Hospital NHS Foundation Trust, London, GBR.
Cureus. 2024 Sep 26;16(9):e70274. doi: 10.7759/cureus.70274. eCollection 2024 Sep.
Good's syndrome is a rare secondary immunodeficiency characterised by recurrent infection and hypogammaglobulinemia associated with thymus tumour, and symptoms of recurrent infection may persist even after thymectomy. It is characterised by increased susceptibility to bacterial, viral, and fungal infections, as well as autoimmunity. Immunoglobulin replacement therapy has been reported to decrease infection rate, hospitalization, and the rate of antibiotic use in these patients. There are very few reported cases of patients with COVID-19 infection and Good's syndrome; however, there is no strong association proven between these two situations. The patient we report in this article had a COVID-19 infection first, was incidentally diagnosed with thymoma, and got the symptoms of Good's syndrome after thymectomy.
古德综合征是一种罕见的继发性免疫缺陷病，其特征为反复感染、低丙种球蛋白血症以及合并胸腺肿瘤，即便胸腺切除后，反复感染的症状仍可能持续存在。其特点是对细菌、病毒和真菌感染以及自身免疫的易感性增加。据报道，免疫球蛋白替代疗法可降低这些患者的感染率、住院率和抗生素使用率。关于新冠肺炎感染合并古德综合征的病例报道极少；然而，尚未证实这两种情况之间存在密切关联。我们在本文中报告的患者先是感染了新冠肺炎，随后偶然诊断出胸腺肿瘤，并在胸腺切除术后出现了古德综合征的症状。
