Tokioka Rana, Saito-Sasaki Natsuko, Sawada Yu
Dermatology, University of Occupational and Environmental Health, Kitakyushu, JPN.
Cureus. 2024 Sep 26;16(9):e70288. doi: 10.7759/cureus.70288. eCollection 2024 Sep.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive blood cancer that often presents with skin lesions and can involve other organs, including the bone marrow. Despite initial responses to treatment, most patients eventually experience disease progression. We report the case of an 82-year-old male with a red chest nodule, later diagnosed with BPDCN and acute myeloid leukemia (AML). Dermoscopy revealed reddish-purple dots, and a biopsy confirmed BPDCN. The patient responded to venetoclax and azacitidine but relapsed five months later. This case highlights the importance of early diagnosis of BPDCN and the utility of dermoscopy in this tumor, which can contribute to timely treatment and improved patient outcomes.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种罕见且侵袭性强的血液癌症，常表现为皮肤病变，还可累及包括骨髓在内的其他器官。尽管初始治疗有反应，但大多数患者最终会出现疾病进展。我们报告了一例82岁男性患者，其胸部有红色结节，后来被诊断为BPDCN和急性髓系白血病（AML）。皮肤镜检查发现红紫色斑点，活检确诊为BPDCN。该患者对维奈克拉和阿扎胞苷有反应，但五个月后复发。该病例强调了BPDCN早期诊断的重要性以及皮肤镜检查在这种肿瘤中的作用，这有助于及时治疗并改善患者预后。
