Ken-Eze Udoka C, Papuashvili Papuna, Kandhalu Salini Krishnarao, Mirza Lubna
Internal Medicine, The Limi Hospital, Abuja, NGA.
Internal Medicine, Tbilisi State Medical University, Tbilisi, GEO.
Cureus. 2024 Sep 27;16(9):e70319. doi: 10.7759/cureus.70319. eCollection 2024 Sep.
Post-bariatric surgery hypoglycemia, also recognized as late dumping syndrome or postprandial hyperinsulinemic hypoglycemia, is a complex condition often driven by multifactorial roots, including postoperative anatomical changes, altered gut hormone responses, metabolic shifts, and other hidden conditions, necessitating a multidisciplinary approach for appropriate evaluation and treatment. We present the case of a 36-year-old female nurse who experienced recurrent hypoglycemia following gastric sleeve surgery. Despite significant weight loss and dietary adjustments, she continued to struggle with unstable blood glucose levels. A comprehensive dysglycemia evaluation revealed the presence of an autoimmune disorder consistent with the criteria for latent autoimmune diabetes in adults (LADA), as defined by "The Immunology of Diabetes Society" (IDS). This new diagnosis added complexity to her clinical management, leading us to reassess her treatment strategy. As a result, her treatment plan was modified to include the initiation of insulin and the introduction of the newly FDA-approved teplizumab, which may help delay the progression of autoimmune diabetes. This case underscores the importance of systematic hypoglycemia evaluations in bariatric surgery patients to optimize clinical outcomes. Managing hypoglycemia in these patients requires a collaborative effort involving endocrinologists, surgeons, and nutritionists to ensure the best outcomes and improve the patient's quality of life.
减重手术后低血糖症,也被认为是晚期倾倒综合征或餐后高胰岛素性低血糖症,是一种复杂的病症,通常由多因素根源驱动,包括术后解剖结构变化、肠道激素反应改变、代谢转变以及其他隐匿病症,因此需要多学科方法进行恰当评估和治疗。我们呈现了一名36岁女性护士的病例,她在接受胃袖状切除术后反复出现低血糖症。尽管体重显著减轻且饮食调整,但她仍在不稳定的血糖水平方面苦苦挣扎。全面的血糖异常评估显示存在一种自身免疫性疾病,符合成人隐匿性自身免疫性糖尿病(LADA)的标准,这是由“糖尿病免疫学会”(IDS)定义的。这一新诊断给她的临床管理增添了复杂性,促使我们重新评估她的治疗策略。结果,她的治疗计划被修改,包括开始使用胰岛素以及引入新获得美国食品药品监督管理局(FDA)批准的替普珠单抗,这可能有助于延缓自身免疫性糖尿病的进展。该病例强调了对减重手术患者进行系统性低血糖评估以优化临床结果的重要性。管理这些患者的低血糖症需要内分泌学家、外科医生和营养师的共同努力,以确保获得最佳结果并改善患者的生活质量。