Guthrie Sarah E, Luensmann Doerte, Schulze Marc-Matthias, Woods Jill, Jones Lyndon
Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Clin Ophthalmol. 2024 Oct 22;18:2999-3008. doi: 10.2147/OPTH.S482568. eCollection 2024.
This prospective comparative study aimed to assess the effects on contact lens comfort, dryness, and wear time when symptomatic daily disposable (DD) contact lens (CL) wearers were refit with delefilcon A (DT1) lenses.
Thirty five symptomatic DD CL wearers with dry eye disease as determined according to the TFOS DEWS 2 guidelines, were enrolled and completed the study. Participants wore their habitual DD CLs during an initial assessment and were subsequently refit with DT1 for 1 month. Participants were masked to the study lens type. Subjective ratings of end-of-day comfort and dryness, average wear time, and comfortable wear time were evaluated as primary endpoints.
Of the 35 participants, two participants were classified as aqueous deficient dry eye, while the remaining participants exhibited symptoms primarily due to evaporative causes. The median CLDEQ-8 score for dryness significantly improved from 17 (fair) with habitual lenses to 13 (good) with DT1 lenses (p < 0.01). Participants reported significantly better end-of-day comfort (p = 0.01) and less end-of-day dryness (p = 0.01) with DT1 compared to their habitual DD lenses. The comfortable wear time was significantly longer with DT1 (8.5 ± 4.1 hours) compared to habitual DD lenses (6.7 ± 3.2 hours) (p = 0.04). No significant differences were observed in vision ratings (p = 0.07).
Refitting symptomatic DD CL wearers with DT1 resulted in improved end-of-day comfort, reduced end-of-day dryness, and extended comfortable wear time compared to their habitual lenses. These findings suggest that DT1 may offer benefits for symptomatic DD wearers with dry eye disease.
这项前瞻性比较研究旨在评估有症状的日抛型（DD）隐形眼镜佩戴者改用delefilcon A（DT1）镜片后对隐形眼镜舒适度、干眼程度和佩戴时间的影响。
根据TFOS DEWS 2指南确定的35名患有干眼病的有症状DD隐形眼镜佩戴者被纳入并完成了研究。参与者在初始评估期间佩戴其惯用的DD隐形眼镜，随后改用DT1镜片佩戴1个月。参与者对研究镜片类型不知情。将日终舒适度和干眼程度的主观评分、平均佩戴时间和舒适佩戴时间作为主要终点进行评估。
35名参与者中，两名参与者被归类为水液缺乏型干眼，其余参与者主要表现出由蒸发原因导致的症状。干眼程度的CLDEQ-8评分中位数从佩戴惯用镜片时的17分（一般）显著提高到佩戴DT1镜片时的13分（良好）（p<0.01）。与惯用的DD镜片相比，参与者报告使用DT1镜片时日终舒适度显著更好（p=0.01），日终干眼程度更低（p=0.01）。与惯用的DD镜片（6.7±3.2小时）相比，DT1镜片的舒适佩戴时间显著更长（8.5±4.1小时）（p=0.04）。视力评分未观察到显著差异（p=0.07）。
与惯用镜片相比，为有症状的DD隐形眼镜佩戴者改用DT1镜片可提高日终舒适度，减轻日终干眼程度，并延长舒适佩戴时间。这些发现表明，DT1可能对患有干眼病的有症状DD佩戴者有益。
