中性粒细胞与淋巴细胞比值（NLR）在睾丸癌中的诊断和预后作用
Diagnostic and prognostic role of NLR in testicular cancer.
作者信息
Sarejloo Shirin, Babadi Saghar, Khanzadeh Shokoufeh, Salimi Amirhossein, Clark Alec, Khazaeli Dinyar, Khanzadeh Monireh, Ghaedi Arshin, Lucke-Wold Brandon
机构信息
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz 767545, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz 868765, Iran.
出版信息
Explor Target Antitumor Ther. 2024;5(6):1177-1198. doi: 10.37349/etat.2024.00270. Epub 2024 Sep 19.
BACKGROUND
To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa).
METHODS
The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review.
RESULTS
NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa.
DISCUSSION
NLR has a significant diagnostic and prognostic value in tCa.
背景
总结现有研究结果，以探讨中性粒细胞与淋巴细胞比值（NLR）在睾丸癌（tCa）中的作用。
方法
截至2021年11月21日，在PubMed、Scopus和Web of Science上进行检索。最终，本综述共纳入31项研究。
结果
与健康对照和良性睾丸病变相比，tCa患者的NLR更高，睾丸切除术后显著降低。NLR升高预示预后不良、晚期、存在淋巴结或远处转移、对侧肿瘤发展、癌症特异性死亡时间缩短、总生存期较差以及对化疗反应较差。然而，NLR无法区分精原细胞瘤和非精原细胞瘤性tCa。
讨论
NLR在tCa中具有重要的诊断和预后价值。
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