Chu Kuan-Hua, Chiang Bor-Luen
Department of Pediatrics, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan.
Genomes and Systems Biology Degree Program, College of Life Science, National Taiwan University, Taipei, Taiwan.
Clin Rev Allergy Immunol. 2024 Dec;67(1-3):73-82. doi: 10.1007/s12016-024-09009-y. Epub 2024 Oct 28.
Regulatory T (Treg) cells are crucial for maintaining immune tolerance by suppressing response to self-antigens and harmless antigens to prevent autoimmune diseases and uncontrolled immune responses. Therefore, using Treg cells is considered a therapeutic strategy treating inflammatory diseases. Based on their origin, Treg cells are classified into thymus-derived, peripherally induced, and in vitro induced Treg cells. Our group discovered a novel Treg cell subset, namely, Treg-of-B (Treg/B) cells, generated by culturing CD4CD25 T cells with B cells, including Peyer's patch B cells, splenic B cells and peritoneal B1a cells, for 3 days. Treg/B cells express CD44, OX40 (CD134), cytotoxic T-lymphocyte-associated antigen-4 (CD152), glucocorticoid-induced tumor necrosis factor receptor family-related protein (CD357), interleukin-10 receptor, lymphocyte activation gene-3 (CD223), inducible co-stimulator (CD278), programmed-death 1 (CD279), tumor necrosis factor receptor II, and high levels of IL-10, but not forkhead box protein P3, similar to type 1 Treg (Tr1) cells. However, unlike Tr1 cells, Treg/B cells do not express CD103, CD226, and latency-associated peptide. Treg/B cells have been applied for the treatment of some murine models of inflammatory diseases, including allergic asthma, inflammatory bowel disease, collagen-induced arthritis, gout, psoriasis and primary biliary cholangitis. This review summarizes the current knowledge of Treg/B cells.
调节性T（Treg）细胞对于维持免疫耐受至关重要，它通过抑制对自身抗原和无害抗原的反应来预防自身免疫性疾病和不受控制的免疫反应。因此，使用Treg细胞被认为是一种治疗炎症性疾病的策略。根据其来源，Treg细胞可分为胸腺来源的、外周诱导的和体外诱导的Treg细胞。我们的研究小组发现了一种新型的Treg细胞亚群，即B细胞来源的Treg（Treg/B）细胞，它是通过将CD4CD25 T细胞与B细胞（包括派尔集合淋巴结B细胞、脾B细胞和腹膜B1a细胞）共培养3天而产生的。Treg/B细胞表达CD44、OX40（CD134）、细胞毒性T淋巴细胞相关抗原4（CD152）、糖皮质激素诱导的肿瘤坏死因子受体家族相关蛋白（CD357）、白细胞介素-10受体、淋巴细胞激活基因3（CD223）、诱导性共刺激分子（CD278）、程序性死亡1（CD279）、肿瘤坏死因子受体II，以及高水平的IL-10，但不表达叉头框蛋白P3，类似于1型调节性T（Tr1）细胞。然而，与Tr1细胞不同的是，Treg/B细胞不表达CD103、CD226和潜伏期相关肽。Treg/B细胞已被应用于治疗一些炎症性疾病的小鼠模型，包括过敏性哮喘、炎症性肠病、胶原诱导的关节炎、痛风、银屑病和原发性胆汁性胆管炎。这篇综述总结了目前关于Treg/B细胞的知识。
