Flæng Simon, Granfeldt Asger, Adelborg Kasper, Sørensen Henrik Toft
Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Eur J Haematol. 2025 Feb;114(2):285-292. doi: 10.1111/ejh.14329. Epub 2024 Oct 28.
Disseminated intravascular coagulation (DIC) is a devastating disease of the coagulation system. We examined the association between ABO blood type and short-term mortality in patients with infection-associated DIC.
The study cohort was drawn from the Danish Disseminated Intravascular Coagulation (DANDIC) cohort. Our subcohort was restricted to patients with infection-associated DIC. All-cause 30-day and 90-day mortality were computed by Kaplan-Meier estimates and odds ratios between ABO blood types were examined using logistic regression analysis adjusted for age, sex, comorbidity, and location of infection. Blood type O was used as a reference.
The DANDIC cohort included 3023 patients with DIC. Among these, 1853 (61%) had infection-associated DIC. Data on ABO blood type were unavailable in 34 patients (1.8%), who were excluded. The median age was 68 years and 58.2% were males. The 30-day mortality ranged between 38.6% and 42.5% and the 30-day mortality odds ratios were 1.15 (95% confidence interval (CI), 0.92-1.42) for blood type A; 0.84 (95% CI, 0.49-1.43) for AB; and 0.95 (95% CI, 0.67-1.33) for B compared to blood type O.
We found no clinically meaningful difference in short-term mortality between the various ABO blood types in patients with infection-associated DIC.
弥散性血管内凝血（DIC）是一种严重的凝血系统疾病。我们研究了ABO血型与感染相关性DIC患者短期死亡率之间的关联。
研究队列来自丹麦弥散性血管内凝血（DANDIC）队列。我们的亚队列仅限于感染相关性DIC患者。采用Kaplan-Meier估计法计算全因30天和90天死亡率，并使用经年龄、性别、合并症和感染部位调整的逻辑回归分析检查ABO血型之间的比值比。以O型血作为对照。
DANDIC队列包括3023例DIC患者。其中，1853例（61%）患有感染相关性DIC。34例患者（1.8%）无法获得ABO血型数据，这些患者被排除。中位年龄为68岁，男性占58.2%。30天死亡率在38.6%至42.5%之间，与O型血相比，A型血的30天死亡比值比为1.15（95%置信区间（CI），0.92 - 1.42）；AB型血为0.84（95%CI，0.49 - 1.43）；B型血为0.95（95%CI，0.67 - 1.33）。
我们发现感染相关性DIC患者的不同ABO血型之间在短期死亡率上没有临床意义上的差异。
