Center of Clinical Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Medicine (Baltimore). 2024 Oct 4;103(40):e39801. doi: 10.1097/MD.0000000000039801.
The association between early pregnancy ultrasound parameters and reproductive hormone levels was investigated through a case-control study. Participants for this retrospective study were recruited from obstetrics and gynecology departments across multiple tertiary care centers over 2 years. Inclusion criteria for the case group included pregnant women in their first trimester with detailed ultrasound data, while the control group comprised nonpregnant women without hormonal disorders. A sample size of 850 was estimated to provide sufficient power for detecting differences in hormone levels. Hormone levels were assayed using enzyme-linked immunosorbent assay, and statistical analysis was performed using Statistical Package for the Social Sciences 26.0. A total of 425 participants in each group were included after accounting for dropouts. For hCG, a strong positive correlation was observed with crown-rump length (R = 0.62, P < .001), gestational sac diameter (R = 0.59, P < .001), and a moderate correlation with yolk sac diameter (R = 0.40, P = .003). Progesterone levels exhibited moderate positive correlations with these ultrasound parameters, and estradiol levels demonstrated strong positive correlations. Conversely, follicle-stimulating hormone levels showed a moderate negative correlation with ultrasound measurements, while luteinizing hormone levels indicated a slight negative correlation. Prolactin levels were positively correlated with all ultrasound parameters in cases. The control group did not show any significant correlations between hormone levels and ultrasound parameters. The study concluded a significant association between early pregnancy ultrasound parameters and reproductive hormone levels in pregnant women, underscoring the potential of these hormones as biomarkers for pregnancy development.
本病例对照研究旨在探讨早孕期超声参数与生殖激素水平之间的关系。本回顾性研究的参与者在 2 年内从多个三级保健中心的妇产科招募。病例组纳入标准为具有详细超声数据的孕 1 周孕妇，对照组为无激素紊乱的非孕妇。估计需要 850 名样本量，以提供检测激素水平差异的足够效力。使用酶联免疫吸附试验测定激素水平，使用社会科学统计软件包 26.0 进行统计分析。考虑到脱落者，每组纳入 425 名参与者。对于 hCG，与头臀长（R=0.62，P<.001）、孕囊直径（R=0.59，P<.001）呈强正相关，与卵黄囊直径呈中度相关（R=0.40，P=.003）。孕酮水平与这些超声参数呈中度正相关，雌二醇水平呈强正相关。相反，卵泡刺激素水平与超声测量呈中度负相关，而黄体生成素水平呈轻度负相关。催乳素水平与病例组的所有超声参数均呈正相关。对照组中激素水平与超声参数之间没有显著相关性。该研究得出结论，早孕期超声参数与孕妇生殖激素水平之间存在显著关联，这强调了这些激素作为妊娠发育生物标志物的潜力。
