Sanmiguel Serpa Luis Carlos, de Visschere Pieter, Speeckaert Marijn, Pullens Pim
Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.
Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
J Magn Reson Imaging. 2025 May;61(5):2157-2168. doi: 10.1002/jmri.29638. Epub 2024 Oct 28.
Multiparametric MRI (mpMRI) provides detailed insights into renal function, but the impact of anthropometric factors on renal imaging is not fully understood.
To investigate regional correlations between mpMRI parameters and age, body mass index (BMI), and body surface area (BSA).
Prospective, cross-sectional observational study.
Twenty-nine healthy volunteers (44.5 ± 18.3 years, 18 females) without a history of renal disease.
FIELD STRENGTH/SEQUENCE: 3-T, pseudo-continuous arterial spin labeling, multi-echo gradient-recalled echo, diffusion-weighted imaging, T and T mapping.
Bilateral kidneys were segmented into nine concentric layers (outer cortex to inner regions) and nine equiangular sections (lower to upper pole). Key parameters (renal blood flow [RBF], , apparent diffusion coefficient [ADC], T and T maps) were correlated with age, BMI, and BSA. Differences in parameters between age and BMI groups were also evaluated.
Spearman correlation, Mann-Whitney U test, and rank-biserial correlation coefficient for effect size. A P-value <0.05 was considered statistically significant.
RBF correlated negatively with age in all regions and BMI in inner layers and lower pole. ADC negatively correlated with BMI (significance was not reached in layers 2, 7, 8; P-value = 0.06-0.12) and BSA in layers 1-7. T negatively correlated with age in inner regions and lower medial pole. Significant positive correlations were found between age and (outermost layer, upper pole), age and T (inner and cranial-caudal regions), as well as BMI and T (except upper pole; P-value = 0.06). Significant differences between age groups were observed for RBF (all regions), (outermost and second innermost layers, central lateral region), T (innermost layer), and T (upper medial pole). Between BMI groups, ADC (middle layers, upper medial pole) and T (outermost and inner layers, lower pole to lateral region) differed significantly.
Intrarenal variance of mpMRI parameters correlated with age, BMI, and BSA.
4 TECHNICAL EFFICACY: Stage 1.
多参数磁共振成像（mpMRI）可提供有关肾功能的详细信息，但人体测量学因素对肾脏成像的影响尚未完全了解。
研究mpMRI参数与年龄、体重指数（BMI）和体表面积（BSA）之间的区域相关性。
前瞻性横断面观察性研究。
29名无肾脏疾病史的健康志愿者（44.5±18.3岁，18名女性）。
场强/序列：3-T，伪连续动脉自旋标记，多回波梯度回波，扩散加权成像，T和T映射。
将双侧肾脏分为9个同心层（从外层皮质到内部区域）和9个等角截面（从下极到上极）。关键参数（肾血流量[RBF]、，表观扩散系数[ADC]，T和T映射）与年龄、BMI和BSA相关。还评估了年龄和BMI组之间参数的差异。
Spearman相关性、Mann-Whitney U检验和效应大小的等级双列相关系数。P值<0.05被认为具有统计学意义。
RBF在所有区域与年龄呈负相关，在内层和下极与BMI呈负相关。ADC与BMI呈负相关（在第2层到第7层未达到显著性；P值=0.06-0.12），在第1层到第7层与BSA呈负相关。T在内侧区域和下内侧极与年龄呈负相关。在最外层和上极、年龄和T（内部和头尾区域）以及BMI和T（上极除外；P值=0.06）之间发现显著正相关。在年龄组之间，观察到RBF（所有区域）、（最外层和第二最内层、中央外侧区域）、T（最内层）和T（上内侧极）存在显著差异。在BMI组之间，ADC（中层、上内侧极）和T（最外层和内层、下极到外侧区域）存在显著差异。
mpMRI参数的肾内差异与年龄、BMI和BSA相关。
4 技术效能：1级。
