定量肺超声检查结果与实验性支气管肺发育不良中的放射状肺泡计数相关。
Quantitative lung ultrasound findings correlate with radial alveolar count in experimental bronchopulmonary dysplasia.
作者信息
Catozzi Chiara, Modena Angelo, Storti Matteo, Ricci Francesca, Villetti Gino, De Luca Daniele
机构信息
Neonatology and Pulmonary Rare Disease Unit, Experimental Pharmacology and Translational Science Department Corporate Preclinical R&D, Chiesi Farmaceutici, Parma, Italy.
Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy.
出版信息
Ultrasound J. 2024 Oct 28;16(1):46. doi: 10.1186/s13089-024-00389-y.
We investigated the relationship between the degree of alveolarization and ultrasound-assessed lung aeration in a validated preterm rabbit model of experimental bronchopulmonary dysplasia (BPD). Lung ultrasound findings were heterogeneously abnormal and consisted of zones with interstitial, interstitial-alveolar or consolidated patterns. The median radial alveolar count was 10.1 [8.4-11.5], 7.8 [6.1-9] and 7.3 [1.8-10.1] in rabbits with interstitial, interstitial-alveolar or consolidated ultrasound pattern, respectively (overall p = 0.036). Alveolar count and lung ultrasound score were significantly correlated (ρ = - 0.044 (95%CI: - 1; - 0.143), p = 0.009; τ = - 0.362 (95%CI: - 0.6; - 0.1), p = 0.017).
我们在经过验证的早产兔实验性支气管肺发育不良（BPD）模型中，研究了肺泡化程度与超声评估的肺通气之间的关系。肺部超声检查结果呈现出异质性异常，包括间质、间质-肺泡或实变模式的区域。间质、间质-肺泡或实变超声模式的兔的平均径向肺泡计数分别为10.1 [8.4 - 11.5]、7.8 [6.1 - 9]和7.3 [1.8 - 10.1]（总体p = 0.036）。肺泡计数与肺部超声评分显著相关（ρ = - 0.044（95%CI：- 1；- 0.143），p = 0.009；τ = - 0.362（95%CI：- 0.6；- 0.1），p = 0.017）。
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