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新西兰奥克兰地区肾衰竭和肾移植的地理差异:基于人群的数据分析研究。

Geographic variation in kidney failure and transplantation in Aotearoa New Zealand: A population-based data linkage study.

机构信息

Department of Nephrology, Te Whatu Ora Waitaha Canterbury, Christchurch, New Zealand.

School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

出版信息

Nephrology (Carlton). 2024 Dec;29(12):941-954. doi: 10.1111/nep.14409. Epub 2024 Oct 28.

DOI:10.1111/nep.14409
PMID:39467040
Abstract

AIM

This study aimed to describe the epidemiology of kidney replacement therapy (KRT) in Aotearoa New Zealand and assess the impact of residential location on access to kidney transplantation.

METHODS

AcceSS and Equity in Transplantation (ASSET), a health-linked data platform, was used to identify people commencing KRT in New Zealand from 2006 to 2019 and analyse regional epidemiology. Health services were classified as 'transplanting', 'intermediate' or 'remote' depending on their degree of separation from a transplant centre. Multiple logistic regression modelling was used to assess the predictors of deceased donor waitlisting or living donor transplantation within 6 months after starting KRT. Web-based mapping software was used to develop interactive geospatial maps.

RESULTS

The cohort was 7704 people newly starting KRT. Living in an intermediate [odds ratio (OR): 0.73 (95% confidence interval (CI): 0.61-0.88)] or remote [OR: 0.38 (95% CI: 0.27-0.54)) region and Māori (OR: 0.35 (95% CI: 0.28-0.44)], Pacific [OR: 0.32 (95% CI: 0.24-0.42)) and Asian (OR: 0.66 (95% CI: 0.50-0.87)] ethnicity were associated with a decreased likelihood of timely waitlisting or transplantation. Regional maps can be explored here.

CONCLUSION

There is marked geospatial and ethnic variation in the epidemiology of kidney failure and access to kidney transplantation across New Zealand. Geospatial mapping of kidney failure epidemiology and transplantation outcomes can provide opportunities to direct resources towards populations at greatest need.

摘要

目的

本研究旨在描述新西兰肾替代治疗(KRT)的流行病学,并评估居住地点对肾移植机会的影响。

方法

利用健康相关数据平台 AcceSS 和移植公平性(ASSET),识别 2006 年至 2019 年期间在新西兰开始接受 KRT 的患者,并分析区域流行病学。根据与移植中心的距离,将医疗服务分为“移植”、“中间”或“远程”。采用多因素逻辑回归模型评估开始 KRT 后 6 个月内等待死亡供体移植或活体供体移植的预测因素。使用基于网络的地图软件制作交互式地理空间地图。

结果

该队列包括 7704 名新开始接受 KRT 的患者。居住在中间[比值比(OR):0.73(95%置信区间(CI):0.61-0.88)]或偏远地区[OR:0.38(95% CI:0.27-0.54)],毛利人(OR:0.35(95% CI:0.28-0.44)]、太平洋岛民[OR:0.32(95% CI:0.24-0.42)]和亚洲人[OR:0.66(95% CI:0.50-0.87)]与及时等待名单或移植的可能性降低相关。可以在此处探索区域地图。

结论

新西兰各地肾衰的流行病学和肾移植机会存在明显的地理空间和种族差异。对肾衰流行病学和移植结果进行地理空间映射可以为有需要的人群提供资源导向的机会。

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Geographic variation in kidney failure and transplantation in Aotearoa New Zealand: A population-based data linkage study.新西兰奥克兰地区肾衰竭和肾移植的地理差异:基于人群的数据分析研究。
Nephrology (Carlton). 2024 Dec;29(12):941-954. doi: 10.1111/nep.14409. Epub 2024 Oct 28.
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AcceSS and Equity in Transplantation (ASSET) New Zealand: Protocol for population-wide data linkage platform to investigate equity in access to kidney failure health services in New Zealand.新西兰移植的可及性和公平性(ASSET):利用人群范围的数据链接平台研究新西兰肾衰竭卫生服务获取公平性的方案。
PLoS One. 2022 Aug 25;17(8):e0273371. doi: 10.1371/journal.pone.0273371. eCollection 2022.
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Clin J Am Soc Nephrol. 2021 Feb 8;16(2):241-250. doi: 10.2215/CJN.09140620. Epub 2021 Jan 26.
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