Ren Guoqiang, Zhang Mingxuan, Zhuang Liping, Li Lianhui, Zhao Shunying, Guo Jinxiu, Zhao Yinchao, Peng Zhaoxiang, Lian Jiangfan, Liu Botao, Ma Jingyun, Hu Xiaodong, Zhang Zhewei, Zhang Ting, Lu Qifeng, Hao Mingming
The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315046, P. R. China.
School of CHIPS, XJTLU Entrepreneur College (Taicang), Xi'an Jiaotong-Liverpool University, Taicang, Suzhou, Jiangsu, 215400, China.
Microsyst Nanoeng. 2024 Oct 29;10(1):156. doi: 10.1038/s41378-024-00805-2.
The exploration of multi-dimensional brain activity with high temporal and spatial resolution is of great significance in the diagnosis of neurological disease and the study of brain science. Although the integration of electroencephalogram (EEG) with magnetic resonance imaging (MRI) and computed tomography (CT) provides a potential solution to achieve a brain-functional image with high spatiotemporal resolution, the critical issues of interface stability and magnetic compatibility remain challenging. Therefore, in this research, we proposed a conductive hydrogel EEG electrode with an asymmetrical bilayer structure, which shows the potential to overcome the challenges. Benefiting from the bilayer structure with different moduli, the hydrogel electrode exhibits high biological and mechanical compatibility with the heterogeneous brain-electrode interface. As a result, the impedance can be reduced compared with conventional metal electrodes. In addition, the hydrogel-based ionic conductive electrodes, which are free from metal conductors, are compatible with MRI and CT. Therefore, they can obtain high spatiotemporal resolution multi-dimensional brain information in clinical settings. The research outcome provides a new approach for establishing a platform for early diagnosis of brain diseases and the study of brain science.
以高时间和空间分辨率探索多维脑活动在神经疾病诊断和脑科学研究中具有重要意义。尽管脑电图（EEG）与磁共振成像（MRI）和计算机断层扫描（CT）的整合为实现具有高时空分辨率的脑功能图像提供了一种潜在解决方案，但界面稳定性和磁兼容性等关键问题仍然具有挑战性。因此，在本研究中，我们提出了一种具有不对称双层结构的导电水凝胶EEG电极，它显示出克服这些挑战的潜力。受益于具有不同模量的双层结构，水凝胶电极与异质脑-电极界面具有高生物和机械兼容性。结果，与传统金属电极相比，阻抗可以降低。此外，基于水凝胶的离子导电电极不含金属导体，与MRI和CT兼容。因此，它们可以在临床环境中获得高时空分辨率的多维脑信息。该研究成果为建立脑疾病早期诊断平台和脑科学研究提供了一种新方法。
