Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA.
Clin Sci (Lond). 2024 Nov 6;138(21):1371-1375. doi: 10.1042/CS20241405.
The commentary discusses the regenerative capacity of the kidneys; recent studies reveal that renal cells can regenerate when exposed to certain conditions. A major focus is on scattered tubular-like cells (STCs), which can dedifferentiate and acquire progenitor-like properties in response to injury. These cells exhibit a glycolytic metabolism, making them resilient to hypoxic conditions and capable of repairing damaged renal tissues. Despite their potential, STCs are difficult to isolate and exist in small numbers. Here we highlight the need for more research into STC function, metabolic profiles, mechanisms limiting STC injury repair capacity, and methods of their pharmacological activation. Understanding these mechanisms could lead to novel therapies for kidney diseases.
这篇评论探讨了肾脏的再生能力；最近的研究表明，肾脏细胞在某些条件下可以再生。一个主要的关注点是散在的管状样细胞（STCs），它们在受到损伤时可以去分化并获得祖细胞样特性。这些细胞表现出糖酵解代谢，使它们能够耐受缺氧条件，并能够修复受损的肾组织。尽管它们有潜力，但 STCs 很难分离且数量较少。在这里，我们强调需要进一步研究 STC 的功能、代谢谱、限制 STC 损伤修复能力的机制以及它们的药理学激活方法。了解这些机制可能为肾脏疾病的治疗提供新的途径。
