绝经后妇女自然绝经年龄与哮喘风险之间的关联。来自加拿大老龄化纵向研究。

The association between age at natural menopause and risk of asthma among postmenopausal women from the Canadian Longitudinal Study on Aging.

机构信息

From the School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.

出版信息

Menopause. 2024 Dec 1;31(12):1069-1077. doi: 10.1097/GME.0000000000002443. Epub 2024 Oct 29.

DOI:10.1097/GME.0000000000002443

PMID:39470604

Abstract

OBJECTIVE

This study aimed to investigate the association between age at natural menopause and incidence of asthma among postmenopausal Canadian women.

METHODS

Women between the ages of 45-85 yr were followed for a 10-yr period. Analysis was restricted to naturally postmenopausal women who are nonsmokers and did not have asthma prior to menopause. Age at natural menopause was examined using the following categories: 40-44, 45-49, 50-54 (reference), and ≥55. Survival analysis was utilized to determine time to onset of asthma. Multivariable Cox regression analysis was performed to assess the relationship between age at natural menopause and asthma after adjusting for covariates.

RESULTS

The multivariable Cox regression analysis showed a 30% decreased risk of asthma in women with age at natural menopause of 40-44 yr compared with age at natural menopause of 50-54 yr with a hazard ratio of 0.7 (95% confidence interval: 0.49-0.95).

CONCLUSIONS

Women with later ages at natural menopause may be at increased risk for asthma.

摘要

目的

本研究旨在探讨加拿大绝经后女性自然绝经年龄与哮喘发病之间的关系。

方法

对 45-85 岁的女性进行了 10 年的随访。分析仅限于自然绝经且绝经前不吸烟且无哮喘的女性。自然绝经年龄分为以下几类：40-44 岁、45-49 岁、50-54 岁（参考值）和≥55 岁。采用生存分析来确定哮喘发病时间。采用多变量 Cox 回归分析，在校正了协变量后，评估自然绝经年龄与哮喘之间的关系。