Hamm Alyshia, Karayeva Evgenia, Oliveira Manoela Lima, Kahouadji Nabil, Grippo Paul, Wolf Patricia G, Mutlu Ece, Tussing-Humphreys Lisa, Kim Sage J
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL 60612, United States.
Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL 60612, United States.
JNCI Cancer Spectr. 2024 Nov 1;8(6). doi: 10.1093/jncics/pkae110.
Chronic exposure to ambient stressors, including neighborhood crime, may have a detrimental impact on the body's stress response system with implications for colorectal carcinogenesis.
We examined associations between the mean neighborhood homicide rates from 2000 and 2018 and diagnosis of colorectal adenoma among patients at the University of Illinois Health and Hospital System in Chicago, Illinois, between 2015 and 2018.
Of the 5225 patients who underwent colonoscopy and were included in the analytic dataset, 60% had colorectal adenoma. Older age, male sex, and higher body mass index (BMI) were associated with greater odds of colorectal adenoma. The neighborhood homicide rate was associated with identifying as Black and Hispanic and higher BMI. A mediation analysis showed that the neighborhood homicide rate effects on colorectal adenoma were mediated through BMI.
The study concluded that older age, male sex, and higher BMI increases the odds of colorectal adenoma, with neighborhood homicide rate indirectly influencing this risk through its association with BMI, particularly among Black and Hispanic individuals.
长期暴露于包括邻里犯罪在内的环境应激源可能会对身体的应激反应系统产生不利影响，进而影响结直肠癌的发生。
我们研究了2000年至2018年伊利诺伊州芝加哥市伊利诺伊大学健康与医院系统患者的邻里平均凶杀率与2015年至2018年期间结直肠腺瘤诊断之间的关联。
在接受结肠镜检查并纳入分析数据集的5225名患者中，60%患有结直肠腺瘤。年龄较大、男性以及较高的体重指数（BMI）与结直肠腺瘤的发生几率较高相关。邻里凶杀率与黑人、西班牙裔身份以及较高的BMI相关。中介分析表明，邻里凶杀率对结直肠腺瘤的影响是通过BMI介导的。
该研究得出结论，年龄较大、男性以及较高的BMI会增加结直肠腺瘤的发生几率，邻里凶杀率通过与BMI的关联间接影响这一风险，尤其是在黑人和西班牙裔个体中。
