Cancer Research Center and Department of Medicine, Department of Pathology, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA,
Dig Dis Sci. 2014 Feb;59(2):446-50. doi: 10.1007/s10620-013-2898-0. Epub 2013 Nov 6.
The disproportionately higher incidence of and mortality from colorectal cancer (CRC) among African Americans (AA) led the American College of Gastroenterology to recommend screening starting at age 45 in 2005.
The purpose of this study was to determine the prevalence of colorectal neoplasia among 40-49-year-old inner city AA and Hispanic Americans (HA).
We reviewed the medical records of 2,435 inner city AA and HA who underwent colonoscopy regardless of indication and compared the prevalence of colorectal neoplasia between AA and HA patients. We used logistic regression models to calculate odds ratios (OR) and 95 % confidence intervals (CI).
There were 2,163 AAs and 272 HA. There were 57 % women in both groups. A total of 158 (7 %) AA and 9 (3 %) HA (P = 0.014) underwent the procedures for CRC screening. When compared to HAs, AAs had higher prevalence of any polyp (35 vs. 18 %, OR = 2.53; 95 % CI 1.82-3.52). Overall, AA had higher prevalence of colorectal neoplasia (adenoma and cancer) when compared to HAs (16 vs. 10 %; OR = 1.68; 95 % CI 1.10-2.56).
We observed a higher frequency of colorectal neoplasia among 40-49-year-old AAs as compared to HAs suggesting an increased susceptibility to CRC risk in this population.
非裔美国人（AA）结直肠癌（CRC）的发病率和死亡率不成比例地较高，这导致美国胃肠病学会在 2005 年建议 45 岁开始筛查。
本研究旨在确定 40-49 岁的城市内非裔美国人和西班牙裔美国人（HA）中结直肠腺瘤的患病率。
我们回顾了 2435 名接受结肠镜检查的城市内 AA 和 HA 的病历，无论其适应症如何，并比较了 AA 和 HA 患者中结直肠腺瘤的患病率。我们使用逻辑回归模型计算比值比（OR）和 95%置信区间（CI）。
AA 中有 2163 人，HA 中有 272 人。两组中女性均占 57%。共有 158 名（7%）AA 和 9 名（3%）HA（P=0.014）进行了 CRC 筛查。与 HA 相比，AA 中任何息肉的患病率更高（35%比 18%，OR=2.53；95%CI 1.82-3.52）。总体而言，与 HA 相比，AA 患有结直肠腺瘤（腺瘤和癌）的患病率更高（16%比 10%；OR=1.68；95%CI 1.10-2.56）。
与 HA 相比，我们观察到 40-49 岁 AA 中结直肠腺瘤的频率更高，这表明该人群患 CRC 的风险增加。
