使用恒河猴食管反流模型对安吉尔奇克抗反流假体进行评估。

Evaluation of the Angelchik antireflux prosthesis using a model for esophageal reflux in rhesus monkeys.

作者信息

Cohen D J, Benjamin S B, Graeber G M, Castell D O, Patrick D H, Cordova C, Dachman A, Friedman A

出版信息

Ann Thorac Surg. 1986 Feb;41(2):135-42. doi: 10.1016/s0003-4975(10)62653-7.

Abstract

Minimal data are available about the Angelchik antireflux prosthesis although it has been inserted in more than 14,000 patients. The present animal study was designed to evaluate the effectiveness and mechanism of action of this prosthesis. A reproducible model of esophageal reflux in primates was created using a double myotomy. Lower esophageal sphincter (LES) pressure and reflux score were improved significantly in animals by insertion of an Angelchik antireflux prosthesis, a modified antireflux prosthesis, or a Nissen fundoplication. Manometrically determined LES length was increased after insertion of an Angelchik antireflux prosthesis but not by a Nissen fundoplication or sham operation. Complications after insertion of the modified prosthesis included intraluminal erosion, fibrous stricture, and slippage of the device over the stomach.

摘要

尽管Angelchik抗反流假体已被植入超过14000名患者体内，但关于它的可用数据却很少。当前的动物研究旨在评估该假体的有效性及作用机制。通过双肌切开术建立了灵长类动物食管反流的可重复模型。植入Angelchik抗反流假体、改良抗反流假体或nissen胃底折叠术可显著改善动物的下食管括约肌（LES）压力和反流评分。植入Angelchik抗反流假体后，通过测压确定的LES长度增加，但nissen胃底折叠术或假手术则无此效果。改良假体植入后的并发症包括腔内侵蚀、纤维性狭窄以及装置在胃上的滑脱。