Sennett M L, Conrad M E
Arch Intern Med. 1986 Feb;146(2):266-7.
In four patients with thrombotic thrombocytopenic purpura (TTP), the administration of plasma exchange and vincristine sulfate was associated with reversal of clinical and hematologic evidence of disease. Plasmapheresis with fresh frozen plasma replacement appears effective in acutely improving neurologic and hematologic abnormalities of patients with TTP and provides time for vincristine to become effective and induce lasting remissions. One patient with early relapse responded to a second short course of vincristine without other therapy. These data suggest that these treatment modalities should be considered as the initial treatment of TTP.
在4例血栓性血小板减少性紫癜（TTP）患者中，血浆置换联合硫酸长春新碱治疗与疾病临床及血液学证据的逆转相关。用新鲜冷冻血浆替代进行血浆置换似乎能有效迅速改善TTP患者的神经和血液学异常，并为长春新碱发挥作用并诱导持久缓解争取时间。1例早期复发患者在未接受其他治疗的情况下，对第二个短疗程的长春新碱治疗有反应。这些数据表明，这些治疗方式应被视为TTP的初始治疗方法。
