Zhu Shanshan, Jin Guorui, He Xiaocong, Li Yuan, Xu Feng, Guo Hui
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
Life Sci. 2024 Dec 15;359:123178. doi: 10.1016/j.lfs.2024.123178. Epub 2024 Oct 28.
Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.
化疗仍然是癌症治疗的基石；然而，其有效性常常因耐药性的产生而受到削弱。最近的研究强调了肿瘤机械微环境（TMME）和新兴的机械纳米医学领域在应对化疗耐药性方面的关键作用。本综述深入分析了旨在通过改变TMME和改进机械纳米医学递送系统来减轻化疗耐药性的机械辅助策略。我们探讨了将异常肿瘤机械特性作为增强癌症化疗疗效的一个有前景途径的潜力，这为推进未来癌症治疗提供了新方向，尤其是从机械医学的角度。
