Hoshino P K, Gaasch W H
Arch Intern Med. 1986 Feb;146(2):349-52.
Symptomatic patients with chronic aortic regurgitation should undergo aortic valve replacement. Asymptomatic patients with normal left ventricular function are not surgical candidates, but aortic valve replacement should be performed in most patients with left ventricular dysfunction, even if symptoms are not yet present. The short-term administration of vasodilators is generally beneficial, but there is only meager evidence that the hemodynamic benefits are maintained; for this reason, the wide application of these agents should be postponed until well-designed clinical trials document a long-term benefit.
有症状的慢性主动脉瓣关闭不全患者应接受主动脉瓣置换术。左心室功能正常的无症状患者不是手术候选对象，但大多数左心室功能不全的患者即使尚未出现症状也应进行主动脉瓣置换术。短期使用血管扩张剂通常有益，但仅有少量证据表明其血液动力学益处能够持续；因此，在精心设计的临床试验证明其长期益处之前，应推迟这些药物的广泛应用。
