Ma Liang, Zhang Zhen, Mu Yulei, Liu Bangheng, Zhou Huiqun, Wang Dong-An
Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, 999077, China.
Centre for Neuromusculoskeletal Restorative Medicine, InnoHK HKSTP, Sha Tin, Hong Kong, 999077, China.
Macromol Biosci. 2025 Mar;25(3):e2400444. doi: 10.1002/mabi.202400444. Epub 2024 Oct 29.
Advancements in biomaterial-based spinal cord tissue engineering technology have profoundly influenced regenerative medicine, providing innovative solutions for both spinal cord organoid development and engineered spinal cord injury (SCI) repair. In spinal cord organoids, biomaterials offer a supportive microenvironment that mimics the natural extracellular matrix, facilitating cell differentiation and organization and advancing the understanding of spinal cord development and pathophysiology. Furthermore, biomaterials are essential in constructing engineered spinal cords for SCI repair. The incorporation of biomaterials with growth factors, fabrication of ordered scaffold structures, and artificial spinal cord assemblies are critical insights for SCI to ensure structural integrity, enhance cell viability, and promote neural regeneration in transplantation. In summary, this review summarizes the contribution of biomaterials to the spinal cord organoids progression and discusses strategies for biomaterial-based spinal cord engineering in SCI therapy. These achievements underscore the transformative potential of biomaterials to improve treatment options for SCI and accelerate future clinical applications.
基于生物材料的脊髓组织工程技术的进步对再生医学产生了深远影响，为脊髓类器官发育和脊髓损伤（SCI）修复工程提供了创新解决方案。在脊髓类器官中，生物材料提供了一个模拟天然细胞外基质的支持性微环境，促进细胞分化和组织形成，并增进了对脊髓发育和病理生理学的理解。此外，生物材料对于构建用于SCI修复的工程化脊髓至关重要。将生物材料与生长因子相结合、制造有序的支架结构以及人工脊髓组件是SCI的关键见解，以确保结构完整性、提高细胞活力并促进移植中的神经再生。总之，本综述总结了生物材料对脊髓类器官进展的贡献，并讨论了基于生物材料的脊髓工程在SCI治疗中的策略。这些成果强调了生物材料改善SCI治疗选择和加速未来临床应用的变革潜力。
