Tajeu Gabriel S, Wu Jingwei, Tewksbury Colleen, Spitzer Jacqueline C, Rubin Daniel J, Gadegbeku Crystal A, Soans Rohit, Allison Kelly C, Sarwer David B
Division of General Internal Medicine and Population Science, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Department of Epidemiology and Biostatistics, Temple University, Philadelphia, Pennsylvania.
Surg Obes Relat Dis. 2025 Mar;21(3):279-287. doi: 10.1016/j.soard.2024.10.004. Epub 2024 Oct 11.
Psychiatric diagnoses are common among adults with severe obesity (body mass index [BMI] ≥40 kg/m) and may be associated with hypertension.
To determine the association between lifetime and current psychiatric diagnoses, separately, with hypertension, uncontrolled blood pressure (BP), and systolic BP (SBP) among adults with severe obesity undergoing metabolic and bariatric surgery (MBS).
Academic medical center.
Outcomes were identified from electronic medical records. Psychiatric diagnoses were assessed by clinical interview and included any bipolar and related disorder or depressive disorders, anxiety, alcohol use disorder, substance use disorder, post-traumatic stress disorder, and eating disorders. Adjusted odds ratios for the association between psychiatric diagnoses and hypertension and uncontrolled BP, separately, were calculated using logistic regression. Linear regression was used to determine the association of psychiatric diagnoses with SBP. Models were adjusted for age, sex, race, and BMI.
There were 281 participants with mean age of 40.5 years (standard deviation = 10.9) and BMI of 45.9 kg/m (standard deviation = 6.2). Participants were predominantly women (86.5%) and Black (57.2%). Overall, 44.8% had hypertension and 32.5% of these individuals had uncontrolled BP. The adjusted odds ratios for hypertension was higher (2.95; 95% confidence interval 1.48-5.87) and SBP was greater (3.50 mm Hg; P = .048) among participants with a lifetime diagnosis of anxiety compared with those without. Participants with any current psychiatric diagnosis had a higher SBP compared to those who did not have a current psychiatric diagnosis (3.62 mm Hg; P = .029).
A diagnosis of anxiety during the lifetime of patients undergoing MBS was associated with almost three times increased odds of hypertension.
精神疾病诊断在重度肥胖(体重指数[BMI]≥40kg/m²)的成年人中很常见,且可能与高血压有关。
分别确定接受代谢和减重手术(MBS)的重度肥胖成年人的终生和当前精神疾病诊断与高血压、血压控制不佳(BP)和收缩压(SBP)之间的关联。
学术医学中心。
从电子病历中确定研究结果。通过临床访谈评估精神疾病诊断,包括任何双相情感障碍及相关障碍或抑郁症、焦虑症、酒精使用障碍、物质使用障碍、创伤后应激障碍和进食障碍。使用逻辑回归分别计算精神疾病诊断与高血压和血压控制不佳之间关联的调整比值比。使用线性回归确定精神疾病诊断与收缩压之间的关联。模型根据年龄、性别、种族和BMI进行了调整。
共有281名参与者,平均年龄为40.5岁(标准差 = 10.9),BMI为45.9kg/m²(标准差 = 6.2)。参与者以女性(86.5%)和黑人(57.2%)为主。总体而言,44.8%的人患有高血压,其中32.5%的人血压控制不佳。与未患焦虑症的参与者相比,终生诊断为焦虑症的参与者患高血压的调整比值更高(2.95;95%置信区间1.48 - 5.87),收缩压更高(3.50mmHg;P = 0.048)。与目前没有精神疾病诊断的参与者相比,目前患有任何精神疾病诊断的参与者收缩压更高(3.62mmHg;P = 0.029)。
接受MBS手术的患者终生诊断为焦虑症与高血压患病几率增加近三倍有关。