Fry D E, Trachtenberg L, Polk H C
Arch Surg. 1986 Mar;121(3):282-4. doi: 10.1001/archsurg.1986.01400030036005.
Continuous intraperitoneal administration of antibiotics has been recommended as treatment for peritonitis. The necessity of simultaneous systemic administration of antibiotics remains undefined but usually is performed. Moxalactam kinetics in serum were studied in dogs receiving 15 mg/kg intravenously; 15 mg/kg intraperitoneally; 5 mg/kg hourly with peritoneal lavage; 15 mg/kg intravenously followed by 5 mg/kg hourly intraperitoneally; 15 mg/kg intraperitoneally after 24 hours of peritonitis; and 5 mg/kg hourly by peritoneal lavage after 24 hours of peritonitis. Intraperitoneally administered moxalactam resulted in sustained serum levels compared with intravenously administered drugs. Repeated exchanges in lavage fluid resulted in progressively higher serum levels with each exchange. Peritonitis results in statistically higher levels of serum antibiotic concentration when compared with controls. Continuous intraperitoneal lavage with antibiotics would not appear to require concomitant systemic drug therapy.
持续腹腔内给予抗生素已被推荐用于治疗腹膜炎。同时全身应用抗生素的必要性尚不明确，但通常会进行。对接受以下给药方式的犬进行了血清中莫拉酰胺动力学研究：静脉注射15mg/kg；腹腔注射15mg/kg；每小时5mg/kg并进行腹腔灌洗；先静脉注射15mg/kg，随后每小时腹腔注射5mg/kg；腹膜炎24小时后腹腔注射15mg/kg；腹膜炎24小时后每小时腹腔灌洗5mg/kg。与静脉给药相比，腹腔内给予莫拉酰胺可使血清水平持续维持。灌洗液的反复更换导致每次更换后血清水平逐渐升高。与对照组相比，腹膜炎导致血清抗生素浓度在统计学上更高。持续腹腔内抗生素灌洗似乎不需要同时进行全身药物治疗。
