Zhang Qi, Dong Liming, Gong Song, Wang Ting
Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Wuhan, China.
Cell Death Discov. 2024 Oct 29;10(1):458. doi: 10.1038/s41420-024-02222-w.
Wound healing is a complex process involving sequential stages of hemostasis, inflammation, proliferation, and remodeling. Multiple cell types and factors, including underlying conditions like diabetes and bacterial colonization, can influence healing outcomes and scar formation. N6-methyladenosine (m6A), a predominant RNA modification, plays crucial roles in gene expression regulation, impacting various biological processes and diseases. m6A regulates embryonic skin morphogenesis, wound repair, and pathophysiological processes like inflammation and angiogenesis. Recent studies have highlighted the role of m6A in wound healing, scar formation, and tissue remodeling. Additionally, m6A presents a unique expression pattern in pathological wounds and scars, potentially influencing wound healing and scar formation through modulating gene expression and cellular signaling, thereby serving as potential biomarkers or therapeutic targets. Targeting m6A modifications are potential strategies to enhance wound healing and reduce scar formation. This review aims to explore the roles and mechanisms of m6A RNA methylation in wound healing and scars, and discuss current challenges and perspectives. Continued research in this field will provide significant value for optimal wound repair and scar treatment.
伤口愈合是一个复杂的过程，涉及止血、炎症、增殖和重塑等连续阶段。多种细胞类型和因素，包括糖尿病和细菌定植等潜在状况，均可影响愈合结果和瘢痕形成。N6-甲基腺苷（m6A）是一种主要的RNA修饰，在基因表达调控中发挥关键作用，影响各种生物学过程和疾病。m6A调节胚胎皮肤形态发生、伤口修复以及炎症和血管生成等病理生理过程。最近的研究强调了m6A在伤口愈合、瘢痕形成和组织重塑中的作用。此外，m6A在病理性伤口和瘢痕中呈现独特的表达模式，可能通过调节基因表达和细胞信号传导影响伤口愈合和瘢痕形成，从而作为潜在的生物标志物或治疗靶点。靶向m6A修饰是促进伤口愈合和减少瘢痕形成的潜在策略。本综述旨在探讨m6A RNA甲基化在伤口愈合和瘢痕中的作用及机制，并讨论当前的挑战和前景。该领域的持续研究将为优化伤口修复和瘢痕治疗提供重要价值。
