Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Sci Rep. 2024 Oct 29;14(1):25959. doi: 10.1038/s41598-024-77600-6.
The impact of appendectomy on the risk of gastrointestinal cancers remains unknown. We aimed to systematically estimate the causal relationship between appendectomy and gastrointestinal cancers in the European population using two-sample Mendelian randomization (TSMR) study methods and meta-analysis. As part of the discovery cohort analysis, we identified independent genetic variants strongly associated with appendectomy from the UK Biobank (50,105 cases) to serve as instrumental variables (IVs). Summary-level data for gastrointestinal cancers were obtained from the FinnGen study. As the replication cohort, IVs associated with appendectomy were extracted in the FinnGen study (28,601 cases). The data for gastrointestinal cancers were obtained from the UK Biobank. Finally, meta-analyses were conducted to evaluate the combined causal effects of the MR results. We found no causal relationship between appendectomy and gastrointestinal cancers in both the discovery and replication cohorts. Finally, the meta-analysis revealed no causal association between appendectomy and gastrointestinal cancers. Our findings suggest no causal relationship exists between appendectomy and gastrointestinal cancers in the European population. This genetic evidence supports the conclusion from other observational studies that appendectomy does not affect the risk of gastrointestinal cancers in the European population.
阑尾切除术对胃肠道癌症风险的影响尚不清楚。我们旨在使用两样本 Mendelian 随机化 (TSMR) 研究方法和荟萃分析，系统地评估欧洲人群中阑尾切除术与胃肠道癌症之间的因果关系。作为发现队列分析的一部分，我们从英国生物库 (50105 例) 中确定了与阑尾切除术密切相关的独立遗传变异，作为工具变量 (IVs)。胃肠道癌症的汇总水平数据来自 FinnGen 研究。作为复制队列，在 FinnGen 研究中提取了与阑尾切除术相关的 IVs（28601 例）。胃肠道癌症的数据来自英国生物库。最后，进行荟萃分析以评估 MR 结果的综合因果效应。我们在发现队列和复制队列中均未发现阑尾切除术与胃肠道癌症之间存在因果关系。最后，荟萃分析显示阑尾切除术与胃肠道癌症之间没有因果关联。我们的研究结果表明，阑尾切除术与欧洲人群的胃肠道癌症之间不存在因果关系。这种遗传证据支持了其他观察性研究的结论，即阑尾切除术不会影响欧洲人群胃肠道癌症的风险。
