Ningbo Medical Center Lihuili Hospital, Ningbo University, No. 57 Xingning Road, Ningbo, Zhejiang, China.
Wenzhou Medical University Renji College, Wenzhou, China.
Sci Rep. 2024 Oct 29;14(1):25913. doi: 10.1038/s41598-024-77725-8.
The relationship between possible sarcopenia and mortality remains ambiguous within Asian populations. To clarify this, we investigated the association in older adults residing in Chinese communities. Utilizing data from the China Health and Retirement Longitudinal Study, this population-based cohort study included individuals aged ≥ 60 years, followed from 2011 to 2012 through 2020. Possible sarcopenia was defined in accordance with the Asian Working Group on Sarcopenia 2019 criteria, and Cox proportional hazards regression was used to analyze its impact on mortality, while exploratory analyses were conducted to investigate the associations of possible sarcopenia with chronic diseases, functional independence, and hospitalization frequency. The study encompassed 5,160 participants (median age: 66 years), nearly half of whom (48.8%) were identified with possible sarcopenia. Over a 9-year follow-up period, there were 1216 recorded deaths. Analysis indicated that individuals with possible sarcopenia faced a significantly elevated mortality risk compared to their counterparts (HR: 1.79, 95% CI: 1.58-2.03; P < 0.001). Further, subgroup analyses confirmed a strong association between possible sarcopenia and all-cause mortality across various subgroups, including those related to sex, obesity status, and living environment. Additionally, exploratory analyses revealed that possible sarcopenia was significantly associated with an increased likelihood of heart disease (OR = 1.18, 95% CI: 1.03-1.34, P = 0.014) and stroke (OR = 1.41, 95% CI: 1.19-1.68, P < 0.001), as well as reduced functional independence (β = -0.17, 95% CI: -0.24--0.10, P < 0.001). Possible sarcopenia was also associated with a higher frequency of hospitalizations at baseline (Exp(β) = 1.50, 95% CI: 1.25-1.81, P < 0.001), although this association was no longer significant during the follow-up period. In conclusion, in Chinese community-dwelling older adults, possible sarcopenia was associated with an increased risk of all-cause mortality, several chronic diseases, and functional dependence. Thus, alleviating or preventing possible sarcopenia may improve health outcomes and extend the lifespan of these individuals.
在亚洲人群中，与可能的肌肉减少症和死亡率之间的关系仍然存在模糊性。为了澄清这一点，我们调查了居住在中国社区的老年人中的关联。这项基于人群的队列研究利用了中国健康与退休纵向研究的数据，纳入了年龄≥60 岁的个体，从 2011 年至 2012 年进行随访至 2020 年。可能的肌肉减少症按照 2019 年亚洲肌肉减少症工作组的标准进行定义，使用 Cox 比例风险回归分析其对死亡率的影响，同时进行探索性分析以研究可能的肌肉减少症与慢性疾病、功能独立性和住院频率的关联。该研究包括 5160 名参与者（中位年龄：66 岁），其中近一半（48.8%）被确定为可能患有肌肉减少症。在 9 年的随访期间，有 1216 人记录死亡。分析表明，与没有肌肉减少症的人相比，有肌肉减少症的人死亡风险显著升高（HR：1.79，95%CI：1.58-2.03；P<0.001）。此外，亚组分析证实，在包括性别、肥胖状况和生活环境在内的各种亚组中，可能的肌肉减少症与全因死亡率之间存在很强的关联。此外，探索性分析表明，可能的肌肉减少症与心脏病（OR=1.18，95%CI：1.03-1.34，P=0.014）和中风（OR=1.41，95%CI：1.19-1.68，P<0.001）的发生风险显著增加以及功能独立性降低（β=-0.17，95%CI：-0.24--0.10，P<0.001）有关。可能的肌肉减少症也与基线时更高的住院频率有关（Exp（β）=1.50，95%CI：1.25-1.81，P<0.001），尽管在随访期间这种关联不再显著。总之，在中国社区居住的老年人中，可能的肌肉减少症与全因死亡率升高、多种慢性疾病和功能依赖有关。因此，缓解或预防可能的肌肉减少症可能会改善这些人群的健康结果并延长其寿命。
