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伴有牙源性角化囊肿的原发性牙源性肿瘤的组织病理学谱：世界上 1 例报道病例，并提出了“更新的诊断标准”。

Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1 reported case of the world with a proposed 'updated diagnostic criteria'.

机构信息

Department of Dental Medicine, College of Medicine and Health Sciences, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.

Department of Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India.

出版信息

Diagn Pathol. 2024 Oct 29;19(1):143. doi: 10.1186/s13000-024-01560-8.

DOI:10.1186/s13000-024-01560-8
PMID:39472990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11520492/
Abstract

BACKGROUND

POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the 1st case of Primordial odontogenic tumor (POT) from Sub-Saharan Africa with unique clinicopathological features; also, this is the first case to report POT's existence as a Hybrid Odontogenic lesion (HOL), with a pertinent review of the literature.

CASE PRESENTATION

This was a 17-year-old patient who presented with slow-growing, painless posterior mandibular swelling. The imaging revealed a well-defined, unilocular, expansile, lytic lesion with internal calcific foci surrounding an impacted #36, indicating a calcifying odontogenic cyst. The incisional biopsy revealed the presence of POT. The tumor was excised along with the involved tooth.

CONCLUSION

POT is predominantly a non-aggressive and mostly affects the pediatric population. Hence, clinicians must be updated on all the aspects of this tumor to diagnose it appropriately and avoid any undue over-or under-treatment.

摘要

背景

POT 是一种相对较新描述的良性牙源性肿瘤，迄今为止登记的病例非常少。我们报告了首例来自撒哈拉以南非洲的原始牙源性肿瘤（POT），具有独特的临床病理特征；此外，这也是首例报告 POT 作为混合性牙源性病变（HOL）存在的病例，并对文献进行了相关回顾。

病例介绍

这是一名 17 岁的患者，表现为缓慢生长、无痛性下颌后牙区肿胀。影像学检查显示一个界限清楚、单房性、膨胀性、溶骨性病变，内部有钙化灶，围绕着一颗埋伏的#36，提示为牙源性钙化囊肿。切开活检显示存在 POT。肿瘤连同受累牙齿被切除。

结论

POT 主要为非侵袭性，多发生于儿童。因此，临床医生必须了解该肿瘤的所有方面，以便进行适当诊断，避免过度或不足治疗。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec1/11520492/2eb69932644a/13000_2024_1560_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec1/11520492/b7cf9dca6645/13000_2024_1560_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec1/11520492/4a2bda410718/13000_2024_1560_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec1/11520492/dc40db0487b2/13000_2024_1560_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec1/11520492/f8a0a15f264f/13000_2024_1560_Fig10_HTML.jpg
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本文引用的文献

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Primordial odontogenic tumour: Report of a novel entity - The third case from India.原始牙源性肿瘤：一种新实体的报告——来自印度的第三例病例
J Oral Maxillofac Pathol. 2023 Jan-Mar;27(1):210-215. doi: 10.4103/jomfp.jomfp_28_22. Epub 2023 Mar 21.
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Primordial odontogenic tumor with prominent calcifications.具有显著钙化的原发性牙源性肿瘤。
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Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.
《头颈部肿瘤第五版世界卫生组织分类更新：牙源性和颌骨肿瘤》。
Head Neck Pathol. 2022 Mar;16(1):63-75. doi: 10.1007/s12105-021-01404-7. Epub 2022 Mar 21.
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Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature.牙源性混合性肿瘤：文献报道的 203 例病例的系统回顾。
J Oral Pathol Med. 2022 Jan;51(1):5-12. doi: 10.1111/jop.13238. Epub 2021 Sep 20.
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Recurrent Primordial Odontogenic Tumor: Epithelium-Rich Variant.复发性原始性牙源性肿瘤：富含上皮型变异。
Head Neck Pathol. 2022 Jun;16(2):550-559. doi: 10.1007/s12105-021-01354-0. Epub 2021 Jul 5.
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Primordial Odontogenic Tumor of Anterior Maxilla in a Young Male: A Case Report and an Updated Review of Literature.上颌前部原始性牙源性肿瘤：1 例报告及文献复习
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Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis.发生在上颌骨的原发性牙源性肿瘤，具有独特的钙化特征及其鉴别诊断要点。
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