Gürkaynak Birsen, Fonseca Dallas R, Suarez Isabella, Stern Michael J, Lo Te-Wen
Biology, Ithaca College, Ithaca, New York, United States.
Research Department, New England Biolabs (United States), Ipswich, Massachusetts, United States.
MicroPubl Biol. 2024 Oct 15;2024. doi: 10.17912/micropub.biology.001374. eCollection 2024.
Fibroblast Growth Factor Receptors (FGFRs) play a role in diverse developmental pathways that mediate cell proliferation, cell migration, and cell survival. We use as a model to better understand FGFR signaling specificity. has a single FGFR, EGL-15 . EGL-15 contains an alternatively spliced exon 5 that results in two isoforms, EGL-15(5A) and EGL-15(5B), that differ in their extracellular domains. The EGL-15(5A) isoform is required for the chemoattraction of a pair of migrating sex myoblasts, whose correct positioning is required for egg laying. Deletion of the 5A domain results in an egg-laying defective (Egl) organism. We identified six highly conserved amino acids within the 5A domain and found that two amino acids, S145 and L148 are specifically required for sex myoblast migration in .
成纤维细胞生长因子受体（FGFRs）在多种发育途径中发挥作用，这些途径介导细胞增殖、细胞迁移和细胞存活。我们以[具体生物名称未给出]作为模型，以更好地理解FGFR信号特异性。[具体生物名称未给出]有一个单一的FGFR，即EGL-15。EGL-15包含一个可变剪接的外显子5，产生两种异构体，EGL-15(5A)和EGL-15(5B)，它们的细胞外结构域不同。EGL-15(5A)异构体是一对迁移的性肌母细胞化学吸引所必需的，其正确定位是产卵所必需的。缺失5A结构域会导致产卵缺陷（Egl）生物体。我们在5A结构域内鉴定出六个高度保守的氨基酸，并发现两个氨基酸，S145和L148是[具体生物名称未给出]中性肌母细胞迁移所特别需要的。
