迈向用于不同环境中智能锌传感的近红外发射激发态质子转移探针。
A Step Toward an NIR-Emitting ESIPT Probe for Smart Zn Sensing in Different Environments.
作者信息
Wang Junfeng, Li Yingbo, Pang Yi
机构信息
Department of Chemistry & Maurice Morton Institute of Polymer Science, The University of Akron, Akron, Ohio 44325, United States.
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, Massachusetts 02114, United States.
出版信息
Chem Biomed Imaging. 2023 May 17;1(6):537-540. doi: 10.1021/cbmi.3c00037. eCollection 2023 Sep 25.
Current sensors for Zn detection are largely based on the photoinduced electron transfer (PET) mechanism, which can effectively change the fluorescence intensity, without inducing a significant spectral shift. By coupling the PET mechanism with an excited state intramolecular proton transfer (ESIPT), a near-infrared fluorescent sensor was developed for Zn detection. Upon binding to the Zn cation, the sensor was able to generate well-separated emission bands (λ ≈ 540 and 770 nm), whose ratio was quite sensitive to the probe's environments. The finding offers an advanced tool for in vitro and in vivo imaging of the Zn cation, which is desirable for future discovery of the biological functions of zinc.
目前用于锌检测的传感器主要基于光诱导电子转移（PET）机制，该机制可以有效改变荧光强度，而不会引起明显的光谱位移。通过将PET机制与激发态分子内质子转移（ESIPT）相结合，开发了一种用于锌检测的近红外荧光传感器。与锌阳离子结合后，该传感器能够产生分离良好的发射带（λ≈540和770nm），其比率对探针的环境非常敏感。这一发现为锌阳离子的体外和体内成像提供了一种先进工具，这对于未来发现锌的生物学功能是非常有必要的。
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