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用于改善生物膜形成的群体感应激动剂的设计与合成及其在生物浸出中的应用

Design and synthesis of quorum-sensing agonist for improving biofilm formation and the application of in bioleaching.

作者信息

Tang Deping, Xi Yanpeng, Song Wentao, Li Mengjiao, Liu Yali, Lin Yanyan, Zhang Ran, Mao Aihong

机构信息

School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, China.

Gansu Provincial Academic Institute for Medical Research, Lanzhou, China.

出版信息

Front Microbiol. 2024 Oct 15;15:1465633. doi: 10.3389/fmicb.2024.1465633. eCollection 2024.

DOI:10.3389/fmicb.2024.1465633
PMID:39473843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11519741/
Abstract

INTRODUCTION

Currently, there are few investigations on the effect of a synthetic exogenous quorum sensing (QS) agonist on the bioleaching rate of ().

METHODS

We created AHL (N-acyl-homoserine lactone) analogues and investigated their effects on biofilm formation, adsorption kinetics, bioleaching, and mechanism.

RESULTS

The findings revealed that N-(3-thiolactone)- dodecylamine (Y3) significantly increased the biofilm formation of in 96-well plates and sulfur sheets. Adsorption tests revealed that Y3 increased the adhesion rate, adsorption constant, and adsorption efficiency. Bioleaching tests indicated that Y3 boosted bioleaching efficiency, with Ni and Cu bioleaching rates increasing by 49.13% and 33.03%, respectively. Transcriptomic analysis revealed that Y3 increased genes associated with QS pathways and biofilm formation, particularly , which was dramatically elevated 42 times.

DISCUSSION

The study laid the groundwork for a better understanding of the mechanics of biofilm formation, which could help improve the potential application of in bioleaching.

摘要

引言

目前，关于合成外源性群体感应（QS）激动剂对（某物质，原文此处未明确）生物浸出率影响的研究较少。

方法

我们合成了AHL（N-酰基高丝氨酸内酯）类似物，并研究了它们对（某物质，原文此处未明确）生物膜形成、吸附动力学、生物浸出及其机制的影响。

结果

研究结果表明，N-(3-硫代内酯)-十二胺（Y3）显著增加了96孔板和硫片上（某物质，原文此处未明确）的生物膜形成。吸附试验表明，Y3提高了粘附率、吸附常数和吸附效率。生物浸出试验表明，Y3提高了生物浸出效率，镍和铜的生物浸出率分别提高了49.13%和33.03%。转录组分析显示，Y3增加了与QS途径和生物膜形成相关的基因，特别是（某基因，原文此处未明确），其显著升高了42倍。

讨论

该研究为更好地理解（某物质，原文此处未明确）生物膜形成的机制奠定了基础，这有助于提高（某物质，原文此处未明确）在生物浸出中的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/c16ca92a63fe/fmicb-15-1465633-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/1b5c29ab5a99/fmicb-15-1465633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/7effdd73e7b0/fmicb-15-1465633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/b94dc547758b/fmicb-15-1465633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/3e907c03aeb1/fmicb-15-1465633-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/ae5688e656a8/fmicb-15-1465633-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/75a26048a4e1/fmicb-15-1465633-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/c16ca92a63fe/fmicb-15-1465633-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/1b5c29ab5a99/fmicb-15-1465633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/7effdd73e7b0/fmicb-15-1465633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/b94dc547758b/fmicb-15-1465633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/3e907c03aeb1/fmicb-15-1465633-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/ae5688e656a8/fmicb-15-1465633-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/75a26048a4e1/fmicb-15-1465633-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d341/11519741/c16ca92a63fe/fmicb-15-1465633-g007.jpg

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