Ma Qing, Jiang Wei, Zhao Qiuyan, Xia Xin, Fang Ronghua
General Practice Ward, International Medical Center Ward, General Practice Medical Center, West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China.
The Center of Gerontology and Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Front Psychiatry. 2024 Oct 15;15:1436541. doi: 10.3389/fpsyt.2024.1436541. eCollection 2024.
Previous studies have consistently documented positive associations between depressive symptoms and altitude; however, a longitudinal study of these relationships among middle-aged and older adult community populations in China has not been previously reported.
We screened 17,705 subjects who met the inclusion criteria from the China Health and Retirement Longitudinal Study database 2011. The altitude is the altitude at which the participants lived in our study area. We estimated the prospective associations between altitude and depressive symptoms among middle-aged and older adults. The 10-item Center for Epidemiological Studies Depression Scale short form was used to measure depressive symptoms. A total of 6,594 participants without depressive symptoms were recruited from the same cohort in 2011 and were followed up in 2018. Multivariate logistic regression was used to assess the associations between altitude and depressive symptoms among middle-aged and older adults.
The prevalence of depressive symptoms was 27.3% in our study. The prevalence of depressive symptoms increased with increasing altitude, and the prevalence of depressive symptoms in women was greater than that in men. Multivariate logistic regression adjusted for all other relevant variables showed that sex, altitude, education level, professional status and marital status were associated with depressive symptoms.
This finding provides evidence of the relationship between altitude and depressive symptoms among middle-aged and older adult community populations in China and shows that depressive symptoms are significantly positively correlated with altitude and other factors, including sex, education level, professional status, and marital status.
以往研究一致记录了抑郁症状与海拔之间的正相关关系；然而，此前尚未有关于中国中老年社区人群中这些关系的纵向研究报道。
我们从2011年中国健康与养老追踪调查数据库中筛选出17705名符合纳入标准的受试者。海拔是指参与者在我们研究区域居住的海拔高度。我们估计了中老年人群中海拔与抑郁症状之间的前瞻性关联。采用10项流行病学研究中心抑郁量表简表来测量抑郁症状。2011年从同一队列中招募了6594名无抑郁症状的参与者，并于2018年进行随访。采用多因素logistic回归分析评估中老年人群中海拔与抑郁症状之间的关联。
我们研究中抑郁症状的患病率为27.3%。抑郁症状的患病率随海拔升高而增加，且女性抑郁症状的患病率高于男性。对所有其他相关变量进行校正后的多因素logistic回归分析显示，性别、海拔、教育水平、职业状况和婚姻状况与抑郁症状有关。
这一发现为中国中老年社区人群中海拔与抑郁症状之间的关系提供了证据，并表明抑郁症状与海拔以及包括性别、教育水平、职业状况和婚姻状况在内的其他因素显著正相关。
