Zhang Beibei, Li Shuli, Ding Juntao, Guo Jingxia, Ma Zhenghai
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China.
Disease Prevention and Control Center of Xinjiang Production and Construction Corps, Urumqi, Xinjiang, China.
iScience. 2024 Sep 24;27(10):111023. doi: 10.1016/j.isci.2024.111023. eCollection 2024 Oct 18.
RAS-like small GTP-binding protein 1b (Rap1b) is a small GTPase involved in numerous deformation-mediated physiological processes, including viral infection, through cytoskeleton regulation on the premise of dynamic changes in the loading state of GTP or GDP. Previous studies have mainly focused on Rap1b's roles in tumor metastasis and platelet hemostasis due to their significant cytoskeleton rearrangement. The complexity of Rap1b and cytoskeleton functions has limited research on their role in viral infections, and the molecular mechanisms for drug and vaccine development targeting Rap1b remain unclear. Here, we reviewed the mechanisms used by Rap1b to sustain cancer growth through the cytoskeleton and analyzed the role of Rap1b protein in the regulation of the cytoskeleton, as well as its use to promote replication in response to viral invasion, highlighting that it may be a potential target for development of antiviral strategies.
RAS样小GTP结合蛋白1b（Rap1b）是一种小GTP酶，通过在GTP或GDP负载状态动态变化的前提下调节细胞骨架，参与包括病毒感染在内的众多变形介导的生理过程。由于其显著的细胞骨架重排，先前的研究主要集中在Rap1b在肿瘤转移和血小板止血中的作用。Rap1b和细胞骨架功能的复杂性限制了对其在病毒感染中作用的研究，针对Rap1b的药物和疫苗开发的分子机制仍不清楚。在这里，我们综述了Rap1b通过细胞骨架维持癌症生长的机制，分析了Rap1b蛋白在细胞骨架调节中的作用，以及其在应对病毒入侵时促进复制的作用，强调它可能是抗病毒策略开发的潜在靶点。
