Zhao Ming, Kang Peipei, Zhu Liling, Zhou Dan, Cui Meimei, Zhang Min, Jia Jingjing, Luo Limei
Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
School of Public Health, Jiamusi University, Jiamusi, China.
iScience. 2024 Sep 19;27(10):110991. doi: 10.1016/j.isci.2024.110991. eCollection 2024 Oct 18.
We analyzed the type-specific persistent infection of high-risk human papillomavirus (HR-HPV) across different continents, aiming to offer valuable insights into the implementation and development of HPV vaccines. There were 129 studies included 656,555 participants. The weighted mean time for any persistent HPV infection was 13.29 months. The single and multiple HPV infection were persistent for median of 12.27 and 18.99 months, respectively. HPV35 is the common genotype of persistent infection in Asia and Africa, as well as HPV53 in Europe. Individuals (>50 years old) were to be more prone to persistent infection. Our study revealed approximately 50% of persistent HPV infection resolved after two years. A 24-month interval for HPV testing is proposed as a way to identify persistent HPV infection. In addition, to develop region-specific guidelines for HPV vaccines can be utilized as references for the diagnosis and treatment of cervical cancer.
我们分析了不同大洲高危型人乳头瘤病毒（HR-HPV）的型别特异性持续感染情况，旨在为HPV疫苗的应用和研发提供有价值的见解。共有129项研究纳入了656,555名参与者。任何持续性HPV感染的加权平均时间为13.29个月。单一和多重HPV感染的持续时间中位数分别为12.27个月和18.99个月。HPV35是亚洲和非洲持续性感染的常见基因型，在欧洲则是HPV53。年龄大于50岁的个体更易发生持续性感染。我们的研究显示，约50%的持续性HPV感染在两年后自行消退。建议以24个月的间隔进行HPV检测，作为识别持续性HPV感染的一种方法。此外，制定针对特定区域的HPV疫苗指南可作为宫颈癌诊断和治疗的参考。
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