School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
Department of Gynecology, Guangdong Provincial Women and Children Hospital, Guangzhou, PR China.
J Infect Public Health. 2021 Jan;14(1):42-49. doi: 10.1016/j.jiph.2020.11.011. Epub 2020 Dec 17.
Previous studies showed the incidence, persistence and clearance of cervical human papillomavirus (HPV) among women varies from regions. There is no study on dynamic changes of HPV infection among women in Guangdong.
It is a retrospective cohort study that included gynecological outpatients aged ≥15 years and retested for HPV within 24 months in Guangdong Women and Children Hospital to estimate HPV incidence, persistence and clearance. Outcomes were estimated through the proportion of HPV incidence, persistence and clearance in HPV-negative or HPV-positive women. Moreover, we examined HPV incidence, persistence and clearance among women who retested in four calendar periods: 0-6, 6-12, 12-18, 18-24 months after the first test.
33,328 gynecological outpatients were included in our study. Incidence rates of any HPV, high-risk (HR) HPV and low-risk (LR) HPV were 10.58%, 8.68% and 4.83%. The most common incident HR HPV were HPV52 (2.69%), HPV16 (1.23%) and HPV58 (1.23%). Persistence rates of any HPV, HR HPV and LR HPV were 47.55%, 42.77% and 33.88%. HPV52 (42.33%), HPV58 (40.74%) and HPV68 (32.36%) were commonly found persistent types. And clearance rates of any HPV, HR HPV and LR HPV were 52.44%, 57.23% and 66.12%.The lowest clearance rates were observed for HPV52 (57.67%), HPV68 (67.64%) and HPV39 (68.56%). HPV incidence and persistence were higher among women aged 15-19 years and ≥55 years. HPV incidence and persistence were found higher among women who retested within 6 months than others in other periods.
HPV52, 58, 68, and 39 were the more likely to cause incident and persistent infection, and less likely to be cleared among women in Guangdong. HPV incidence and persistent infection were higher among women aged both younger and older women compared to middle aged women. HPV retesting period may impact the detection of HPV incidence, persistence and clearance.
先前的研究表明，女性中宫颈人乳头瘤病毒（HPV）的发病率、持续性和清除率因地区而异。目前尚无关于广东女性 HPV 感染动态变化的研究。
这是一项回顾性队列研究，纳入了广东省妇幼保健院年龄≥15 岁的妇科门诊患者，并在 24 个月内对其进行了 HPV 复查，以估计 HPV 阴性或 HPV 阳性女性的 HPV 发病率、持续性和清除率。通过 HPV 阴性或 HPV 阳性女性中 HPV 发病率、持续性和清除率的比例来评估结果。此外，我们检查了在首次检测后 0-6、6-12、12-18 和 18-24 个月四个日历期间复查的女性中 HPV 的发病率、持续性和清除率。
本研究纳入了 33328 名妇科门诊患者。任何 HPV、高危型（HR）HPV 和低危型（LR）HPV 的发病率分别为 10.58%、8.68%和 4.83%。最常见的新发 HR-HPV 为 HPV52（2.69%）、HPV16（1.23%）和 HPV58（1.23%）。任何 HPV、HR-HPV 和 LR-HPV 的持续性分别为 47.55%、42.77%和 33.88%。HPV52（42.33%）、HPV58（40.74%）和 HPV68（32.36%）是常见的持续性 HPV 类型。任何 HPV、HR-HPV 和 LR-HPV 的清除率分别为 52.44%、57.23%和 66.12%。HPV52（57.67%）、HPV68（67.64%）和 HPV39（68.56%）的清除率最低。15-19 岁和≥55 岁的女性 HPV 发病率和持续性更高。与其他时期相比，6 个月内复查的女性 HPV 发病率和持续性更高。
HPV52、58、68 和 39 更有可能导致新发和持续性感染，且在广东女性中更不容易清除。与中年女性相比，年轻和年老女性的 HPV 发病率和持续性感染更高。HPV 复查时间可能会影响 HPV 发病率、持续性和清除率的检测。
