Facultad de Medicina, Centro de Investigación e Innovación Biomédica, Universidad de los Andes, Santiago, Chile.
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, United States.
Front Immunol. 2024 Oct 15;15:1395421. doi: 10.3389/fimmu.2024.1395421. eCollection 2024.
Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attained. Recent research on the role of commensal microbiota in the control of immunity has opened new avenues for the search of novel clinical interventions. Indeed, products of intestinal metabolism generated by both host cells and the microbiota have been identified as modulators of the immune response. Among these, tryptophan (Trp) and its derivatives are being investigated to understand their impact on alloimmunity and their potential usefulness as therapeutic targets to improve allograft survival. Here, we reviewed the latest findings on the contribution of Trp metabolic pathways to transplant outcomes.
长期的免疫抑制药物耐受是移植领域的一个主要目标，但尚未实现。最近关于共生微生物群在免疫控制中的作用的研究为寻找新的临床干预措施开辟了新的途径。事实上，宿主细胞和微生物群产生的肠道代谢产物已被确定为免疫反应的调节剂。在这些代谢产物中，色氨酸（Trp）及其衍生物正在被研究，以了解它们对同种异体免疫的影响及其作为改善移植物存活率的治疗靶点的潜在用途。在这里，我们回顾了色氨酸代谢途径对移植结果的最新贡献。
