Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA; Shanghai Mengniu Biotechnology R&D Co, Ltd, Shanghai, China.
Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.
Am J Transplant. 2023 Feb;23(2):272-277. doi: 10.1016/j.ajt.2022.11.011. Epub 2023 Jan 12.
Intestinal commensals can exert immunomodulatory effects on the host, with beneficial or detrimental consequences depending on underlying diseases. We have previously correlated longer survival of minor mismatched skin grafts in mice with the presence of an intestinal commensal bacterium, Alistipes onderdonkii. In this study, we investigated its sufficiency and mechanism of action. Oral administration of A onderdonkii strain DSM19147 but not DSM108265 was sufficient to prolong minor mismatched skin graft survival through inhibition of tumor necrosis factor production. Through metabolomic and metagenomic comparisons between DSM19147 and DSM108265, we identified candidate gene products associated with the anti-inflammatory effect of DSM19147. A onderdonkii DSM19147 can lower inflammation both at a steady state and after transplantation and may serve as an anti-inflammatory probiotic beneficial for transplant recipients.
肠道共生菌可以对宿主发挥免疫调节作用，其有益或有害的影响取决于潜在的疾病。我们之前的研究表明，在小鼠中，一种肠道共生菌——普通拟杆菌（Alistipes onderdonkii）的存在与次要错配皮肤移植物的存活时间延长相关。在这项研究中，我们研究了它的充分性及其作用机制。口服普通拟杆菌菌株 DSM19147 但不是 DSM108265 足以通过抑制肿瘤坏死因子的产生来延长次要错配皮肤移植物的存活时间。通过 DSM19147 和 DSM108265 之间的代谢组学和宏基因组学比较，我们确定了与 DSM19147 抗炎作用相关的候选基因产物。普通拟杆菌 DSM19147 可以在稳定状态和移植后降低炎症水平，因此可能作为一种抗炎益生菌有益于移植受者。
