Department of Comprehensive Chemotherapy/Head and Neck Cancer, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Immunol. 2024 Oct 15;15:1460480. doi: 10.3389/fimmu.2024.1460480. eCollection 2024.
Some special therapeutic responses may appear during immunotherapy, such as hyperprogression, pseudoprogression and so on. Dissociated response of immunotherapy has been clinically reported in recent years mainly in lung cancer and kidney cancer. Since there were poor prognosis and simple treatment of advanced head and neck cancer, the application of immunotherapy in head and neck cancer has risen in recent years. But the dissociated response of immunotherapy in head and neck cancer is rarely reported. We reported two series of cases of advanced head and neck cancer that showed dissociated response after immunotherapy, tumor progression was assessed by imaging methods such as PET-CT, enhanced CT and enhanced MR, and reviewed the literature related to dissociated response in immunotherapy. We propose that the dissociated response of immunotherapy may affect the treatment strategy of advanced head and neck cancer, but more clinical analyses and researches are needed to confirm it.
免疫治疗期间可能会出现一些特殊的治疗反应，如超进展、假性进展等。近年来，免疫治疗的分离反应主要在肺癌和肾癌中得到临床报告。由于晚期头颈部癌症的预后较差且治疗方法简单，近年来免疫疗法在头颈部癌症中的应用有所增加。但免疫治疗在头颈部癌症中的分离反应很少有报道。我们报告了两系列接受免疫治疗后出现分离反应的晚期头颈部癌症病例，通过 PET-CT、增强 CT 和增强 MR 等影像学方法评估肿瘤进展，并复习了与免疫治疗中分离反应相关的文献。我们提出，免疫治疗的分离反应可能会影响晚期头颈部癌症的治疗策略，但需要更多的临床分析和研究来证实。
