Yasin Ahmed K A, Mohamed Shehab Fareed, Abdalla Elmustafa, Rao Girish, Alkhulaifi Abdulaziz M, Yassin Mohamed A, Mudawi Deena, Al-Mashdali Abdulrahman Fadhl, Kohla Samah, Ibrahim Feryal A, Soliman Dina, Carr Cornelia S
Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
Hematology, Hamad Medical Corporation (HMC), Doha, Qatar.
Case Rep Oncol. 2024 Sep 12;17(1):1008-1013. doi: 10.1159/000541036. eCollection 2024 Jan-Dec.
Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there. In rare cases, also spontaneous coronary artery dissection (SCAD) can be seen.
This case series describes two case reports of MPNs in which SCAD was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted for acute myocardial infarction (MI) and was later found to have PV and SCAD. The second one was about a 52-year-old man who was also admitted for acute MI and was later found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.
MPNs with JAK2 mutations are associated with SCAD in addition to usual atherosclerosis. This association needs further research.
真性红细胞增多症（PV）和原发性血小板增多症等慢性骨髓增殖性肿瘤（MPN）与动脉粥样硬化和心血管事件相关，尤其是存在JAK2突变时。在罕见情况下，也可见自发性冠状动脉夹层（SCAD）。
本病例系列描述了两例MPN病例报告，两例除了标准的动脉粥样硬化外均发现了SCAD。第一例是一名42岁男性，因急性心肌梗死（MI）入院，后来发现患有PV和SCAD。第二例是一名52岁男性，同样因急性MI入院，后来发现患有SCAD和原发性血小板增多症。两例均发现JAK2V617F错义突变。
伴有JAK2突变的MPN除了常见的动脉粥样硬化外还与SCAD相关。这种关联需要进一步研究。
