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用于治疗抵抗性疾病中多微生物激活综合征的诱导天然噬菌体鸡尾酒疗法

Induced Native Phage Cocktails for Multi-microbial Activation Syndrome in Treatment-Resistant Illnesses.

作者信息

Jernigan David A

机构信息

Bioregulatory Medicine, Biologix Center for Optimum Health, Franklin, USA.

出版信息

Cureus. 2024 Oct 28;16(10):e72587. doi: 10.7759/cureus.72587. eCollection 2024 Oct.

Abstract

The global population is plagued by chronic illnesses of many types due to, in part, the activation of virulence of many latent microbes leading to chronic multi-system illness, stimulating the new term, multi-microbial activation syndrome (MMAS). Treatment-resistant infections across the entire microbial spectrum are now largely untreatable using the previously successful pharmaceutical and natural medicine options. The heavy-handed methods of long-term chemotherapeutic antibiotics, antifungals, and antiviral drugs, whose adverse effects could be worse than the original illness, are presently essentially useless in the long run, as microbes have developed rapid adaptive mutations, becoming drug-resistant. The introduction of induced native phage therapy opened a completely new treatment category that has the potential to complement or replace aggressive drug therapies of many classes. Since its introduction, many advancements have been made to the technology. The most recent development in this new treatment genre is the ability to formulate induced native phage cocktails that use a wide spectrum of induction signatures within the formulation to stimulate various types of beneficial phages already living within the phageome of the body, to target a wide range of pathogenic microbes and associated advantageous physiological targets. The ability to address the MMAS commonly seen in various chronic illnesses simultaneously within the same formulation enables greater clinical outcomes without harm to the microbiome or to the tissues and systems of the body.

摘要

全球人口饱受多种慢性疾病的困扰,部分原因是许多潜伏微生物的毒力被激活,导致慢性多系统疾病,从而催生了新术语——多微生物激活综合征(MMAS)。目前,使用先前成功的药物和天然药物选项,基本上无法治疗整个微生物谱中耐药性感染。长期化疗用抗生素、抗真菌药和抗病毒药物的强硬方法,其副作用可能比原发病更严重,从长远来看目前基本上毫无用处,因为微生物已经发生快速适应性突变,产生了耐药性。诱导天然噬菌体疗法的引入开创了一个全新的治疗类别,有可能补充或取代许多类别的激进药物疗法。自引入以来,这项技术已经取得了许多进展。这种新治疗方式的最新进展是能够配制诱导天然噬菌体鸡尾酒,该鸡尾酒在配方中使用广泛的诱导特征,以刺激体内噬菌体组中已经存在的各种有益噬菌体,从而靶向多种致病微生物和相关的有利生理靶点。在同一配方中同时解决各种慢性疾病中常见的MMAS的能力,能够在不损害微生物群或身体组织和系统的情况下实现更好的临床效果。

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