Tsao Hsuan Megan, Huang Ming-Chyi, Liu Tung-Hsia, Chang Hu-Ming, Chung Ren-Hua, Kuo Hsiang-Wei, Chen Andrew C H, Yang Rong-Sen, Liu Yu-Li
Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Department of Addiction Sciences, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
Alcohol Clin Exp Res (Hoboken). 2024 Dec;48(12):2294-2302. doi: 10.1111/acer.15472. Epub 2024 Oct 30.
Alcohol use disorder (AUD) is associated with imbalanced bone turnover and psychological symptoms, but the relationship between bone and brain remains unclear. The study analyzed serum levels of a bone formation marker, procollagen type 1 N-terminal propeptide (P1NP), and bone resorption marker, C-terminal telopeptide of type I collagen (CTX-1), in AUD patients before and after 2 weeks of alcohol withdrawal and investigated their correlation with psychological symptoms.
Ninety patients with AUD and 117 healthy controls were recruited. P1NP and CTX-1 levels were measured using Enzyme-Linked Immunosorbent Assay. The Penn Alcohol Craving Scale (PACS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were assessed in the AUD group at baseline, week 1, and week 2 of withdrawal.
Baseline CTX-1 levels, along with the CTX-1/P1NP and P1NP/CTX-1 ratio, were higher in the AUD group than controls. Over the 2-week withdrawal, PACS, BDI, and BAI scores demonstrated significant reductions. P1NP (p < 0.001) and P1NP/CTX-1 ratio increased (p < 0.001), while CTX-1/P1NP ratio decreased (p < 0.001), indicating a propensity toward bone formation. Univariate analysis revealed that reductions in PACS, BDI, and BAI scores during withdrawal correlated with increased P1NP levels and decreased CTX-1/P1NP ratios. However, multivariate analysis indicated that only PACS score reductions correlated with these changes.
Bone metabolism shifted toward increased bone formation and decreased bone resorption during 2-week alcohol withdrawal. The correlation between improvements in bone turnover markers and reduction in craving scores during withdrawal supports the concept of the bone-brain axis.
酒精使用障碍（AUD）与骨转换失衡及心理症状相关，但骨骼与大脑之间的关系仍不明确。本研究分析了AUD患者在戒酒2周前后骨形成标志物1型前胶原N端前肽（P1NP）和骨吸收标志物I型胶原C端肽（CTX-1）的血清水平，并研究了它们与心理症状的相关性。
招募了90例AUD患者和117名健康对照者。使用酶联免疫吸附测定法测量P1NP和CTX-1水平。在AUD组的基线、戒断第1周和第2周评估宾夕法尼亚酒精渴望量表（PACS）、贝克抑郁量表（BDI）和贝克焦虑量表（BAI）。
AUD组的基线CTX-1水平以及CTX-1/P1NP和P1NP/CTX-1比值均高于对照组。在2周的戒断期内，PACS、BDI和BAI评分显著降低。P1NP（p < 0.001）和P1NP/CTX-1比值升高（p < 0.001），而CTX-1/P1NP比值降低（p < 0.001），表明有骨形成倾向。单因素分析显示，戒断期间PACS、BDI和BAI评分的降低与P1NP水平升高和CTX-1/P1NP比值降低相关。然而，多因素分析表明，只有PACS评分的降低与这些变化相关。
在2周的酒精戒断期内，骨代谢向骨形成增加和骨吸收减少转变。戒断期间骨转换标志物的改善与渴望评分降低之间的相关性支持了骨-脑轴的概念。
