School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Institute of Exact & Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Future Med Chem. 2024;16(20):2169-2188. doi: 10.1080/17568919.2024.2419376. Epub 2024 Oct 30.
Eugenol, a natural compound found in essential oils such as clove oil, has been extensively studied for its diverse biological activities including the therapeutic potential against microbial and parasitic infections. This review provides an overview of the synthetic strategies (shown in Supplementary Material) employed to develop bioactive derivatives and analogues derived from eugenol and related compounds (e.g., dihydroeugenol and isoeugenol), focusing on biological activity of more than 100 bioactive eugenol derivatives against bacterial, fungal, viral and protozoal pathogens. Through a comprehensive survey of literature, this paper shows the impact of structural modifications of these phenylpropanoids on antimicrobial and antiparasitic activity. Key findings highlight promising candidates for further development in antimicrobial drug discovery, suggesting directions for future research in the pursuit of effective therapeutic agents.
丁香酚是一种天然化合物，存在于丁香油等精油中，因其具有多种生物活性而被广泛研究，包括对抗微生物和寄生虫感染的治疗潜力。本综述概述了为开发生物活性衍生物和类似物而采用的合成策略（见补充材料），这些衍生物和类似物源自丁香酚和相关化合物（例如，二氢丁香酚和异丁香酚），重点介绍了 100 多种生物活性丁香酚衍生物对细菌、真菌、病毒和原生动物病原体的活性。通过对文献的全面调查，本文展示了这些苯丙素类化合物结构修饰对抗菌和抗寄生虫活性的影响。主要发现强调了有希望的候选物，可进一步开发用于抗菌药物发现，为追求有效治疗剂的未来研究提供了方向。
