Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
The Walton Centre NHS Foundation Trust, Liverpool, UK.
Mult Scler. 2024 Nov;30(13):1630-1641. doi: 10.1177/13524585241288393. Epub 2024 Oct 30.
The MSIS-29 measures the physical and psychological impact of MS.
The associations between MSIS-29 domains and demographic/clinical aspects were examined and trajectories analysed over time.
Data were collected in the Trajectories of Outcome in Neurological Conditions study for a diverse population of people with MS, with follow-up for up to 5 years. Following Rasch analysis, minimal important change (MIC) was computed for ensuing total, physical and psychological domains.
Fit to the Rasch model using data from 5921 participants validated physical, psychological and total domains, and the conversion table transforms raw scores to interval-level metric equivalents. These domains showed significant differences across demographic (age, gender, employment, education, and marital status) and clinical (subtype, treatment, and duration) factors with large effect sizes. The MIC scores were physical: 9.1, total: 14.1, which were both above measurement error, and psychological: 5.5 which was not, so 1.6% of participants reported psychological change which was clinically important but not statistically significant. Trajectory analysis showed three groups, one stable and two with significant slopes, improving and deteriorating.
The MSIS-29 has shown adequate fit to the Rasch model after accommodating problems with local item dependency, through a bi-factor solution. The domains showed good discrimination across key factors.
MSIS-29 衡量多发性硬化症的生理和心理影响。
研究了 MSIS-29 各领域与人口统计学/临床方面的相关性，并分析了随时间的变化轨迹。
在神经疾病结局轨迹研究中，对来自不同人群的多发性硬化症患者进行了数据收集，随访时间长达 5 年。在进行 Rasch 分析后，计算了随后的总评分、生理评分和心理评分的最小重要变化值（MIC）。
来自 5921 名参与者的数据符合 Rasch 模型，验证了生理、心理和总分领域，转换表将原始分数转换为区间水平的度量等效值。这些领域在人口统计学（年龄、性别、就业、教育和婚姻状况）和临床（亚型、治疗和病程）因素方面存在显著差异，且具有较大的效应量。MIC 评分分别为生理：9.1，总评分：14.1，均高于测量误差，而心理评分：5.5，低于测量误差，因此有 1.6%的参与者报告了具有临床意义但无统计学意义的心理变化。轨迹分析显示，有三个组，一个稳定组和两个斜率显著的组，分别是改善组和恶化组。
在通过双因子解决方案解决局部项目依存性问题后，MSIS-29 已符合 Rasch 模型的要求。各领域在关键因素方面表现出良好的区分度。
