Department of Immunity, Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang, China.
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2420448. doi: 10.1080/21645515.2024.2420448. Epub 2024 Oct 30.
Despite high vaccination coverage in high-income countries, recent reports of pertussis resurgence have heightened public concern about vaccine effectiveness and vaccination. Quzhou City has gradually transitioned from DTwP to DTaP vaccines, achieving a remarkable vaccination coverage rate of 99%. However, since 2024, there has been a significant surge in pertussis cases in Quzhou City. We collected data on pertussis cases, described the epidemiological characteristics of pertussis outbreaks in Quzhou City, examined pertussis vaccination history, and conducted a COX survival analysis. Pertussis cases reported in Quzhou City from January to April 2024 were far higher than those reported in previous years during the same period. Geographically, cases were concentrated in the central region and predominantly affected children under 9 years old, with a focus on the 5-9 age group. Survival analysis revealed that the risk of pertussis incidence increased by 2.84 times (HR = 2.87, 95% CI = 2.27 ~ 3.63) when comparing self-paid vaccines to free vaccines. The pertussis situation in Quzhou City remains critical, emphasizing the need for enhanced immunization strategies and further optimization of pertussis immunization protocols.
尽管高收入国家的疫苗接种率很高，但最近百日咳卷土重来的报告引起了公众对疫苗有效性和接种的关注。衢州市已逐渐将疫苗从 DTwP 转为 DTaP，接种覆盖率达到了惊人的 99%。然而，自 2024 年以来，衢州市百日咳病例显著增加。我们收集了百日咳病例数据，描述了衢州市百日咳暴发的流行病学特征，检查了百日咳疫苗接种史，并进行了 COX 生存分析。衢州市 2024 年 1 月至 4 月报告的百日咳病例远远高于往年同期报告的病例。从地域上看，病例集中在中部地区，主要影响 9 岁以下儿童，以 5-9 岁年龄组为主。生存分析显示，自费疫苗与免费疫苗相比，百日咳发病率的风险增加了 2.84 倍（HR=2.87，95%CI=2.27~3.63）。衢州市的百日咳形势仍然严峻，强调需要加强免疫策略，并进一步优化百日咳免疫方案。
