Istanbul Medeniyet University, Prof. Dr. Suleyman Yalcin City Hospital, Department of Neurosurgery, Istanbul, Türkiye.
Turk Neurosurg. 2024;34(6):1009-1015. doi: 10.5137/1019-5149.JTN.45105-23.3.
To investigate the correlation between specific glioblastoma multiforme (GBM) molecular markers and their proximity to the subventricular zone (SVZ) to uncover potential prognostic indicators and therapeutic strategies.
The study retrospectively analyzed 171 patients who underwent surgery for supratentorial GBM from 2016 to 2022. GBMs were categorized into SVZ contact (SVZ + GBM) and SVZ noncontact (SVZ-GBM) groups. We analyzed molecular markers, such as IDH1, P53, ATRX, Ki67, GFAP, and Olig2.
SVZ + GBM tumors were larger (12.2 cm3) than SVZ-GBM tumors (4.8 cm3; p < 0.001). Additionally, IDH1 mutation was negative in 100% of SVZ-GBM tumors; ATRX loss was more prevalent in SVZ + GBM tumors (34.3%) than in SVZ-GBM tumors (4.5%; p < 0.001). There was no correlation between SVZ contact and the p53 value (p=0.134). Furthermore, no difference was observed in the association of the Ki67 proliferation index and Olig2 positivity with SVZ contact (p=0.306, p=0.071, respectively). However, there was a correlation between IDH1 mutation and SVZ contact, with all IDH1-positive tumors showing SVZ contact (p=0.009).
This study revealed a correlation between SVZ contact in GBM and specific molecular markers, specifically IDH1 mutation, ATRX loss, and tumor size. SVZ contact could serve as criterion for categorizing GBMs, thus contributing to an improved understanding of the disease and potential therapeutic interventions.
研究胶质母细胞瘤（GBM）特定分子标志物与侧脑室下区（SVZ）的接近程度之间的相关性，以揭示潜在的预后指标和治疗策略。
本研究回顾性分析了 2016 年至 2022 年间接受幕上 GBM 手术的 171 例患者。将 GBM 分为 SVZ 接触（SVZ+GBM）和 SVZ 非接触（SVZ-GBM）组。分析了 IDH1、P53、ATRX、Ki67、GFAP 和 Olig2 等分子标志物。
SVZ+GBM 肿瘤（12.2cm3）明显大于 SVZ-GBM 肿瘤（4.8cm3；p<0.001）。此外，SVZ-GBM 肿瘤中 100%存在 IDH1 突变阴性，SVZ+GBM 肿瘤中 ATRX 缺失更为常见（34.3%），SVZ-GBM 肿瘤中 ATRX 缺失较少（4.5%；p<0.001）。SVZ 接触与 p53 值之间无相关性（p=0.134）。此外，Ki67 增殖指数和 Olig2 阳性与 SVZ 接触之间无关联（p=0.306，p=0.071）。然而，IDH1 突变与 SVZ 接触之间存在相关性，所有 IDH1 阳性肿瘤均与 SVZ 接触相关（p=0.009）。
本研究揭示了 GBM 中 SVZ 接触与特定分子标志物之间的相关性，特别是 IDH1 突变、ATRX 缺失和肿瘤大小。SVZ 接触可作为 GBM 分类的标准，从而有助于更好地了解疾病并可能进行治疗干预。
