School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Department of Obstetrics and Gynecology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Br J Hosp Med (Lond). 2024 Oct 30;85(10):1-10. doi: 10.12968/hmed.2024.0279. Epub 2024 Oct 14.
Cervical cancer remains a leading cause of cancer-related mortality among women worldwide, particularly in underdeveloped nations. Despite advances in standard therapies, patients with recurrent metastatic cervical cancer face a poor prognosis and limited treatment options. This study aims to evaluate the efficacy and safety of emerging therapeutic approaches in managing this challenging condition, including immunotherapy, targeted medicines, and chemotherapy. Our review of recent literature and clinical trials highlights the significant progress made in the systematic treatment of metastatic cervical cancer. While each treatment modality has its strengths and limitations, the collective data suggest a trend towards improved patient outcomes with the adoption of these novel therapies. However, the heterogeneity of patient responses underscores the need for personalised treatment strategies. In conclusion, improvements in medical technology and the adoption of tailored treatment approaches have led to promising advancements in the management of recurrent metastatic cervical cancer. To further enhance patient care, there is an urgent need for more extensive clinical trial data and the development of more efficient personalised treatment plans. This study aims to contribute to this effort by comprehensively analysing current therapeutic strategies and identifying areas for future research.
宫颈癌仍然是全世界女性癌症相关死亡的主要原因，特别是在欠发达国家。尽管标准治疗方法有所进展，但患有复发性转移性宫颈癌的患者预后较差，治疗选择有限。本研究旨在评估新兴治疗方法在治疗这种具有挑战性疾病方面的疗效和安全性，包括免疫疗法、靶向药物和化疗。我们对最近的文献和临床试验进行了综述，强调了在转移性宫颈癌的系统治疗方面取得的重大进展。虽然每种治疗方法都有其优势和局限性，但综合数据表明，随着这些新疗法的采用，患者的预后有改善的趋势。然而，患者反应的异质性突出表明需要制定个性化的治疗策略。总之，医疗技术的进步和个性化治疗方法的采用为复发性转移性宫颈癌的治疗带来了有希望的进展。为了进一步提高患者的护理水平，迫切需要更广泛的临床试验数据和更有效的个性化治疗计划。本研究旨在通过全面分析当前的治疗策略并确定未来的研究领域来为此做出贡献。
