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本文引用的文献

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Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 trial.玻璃体内注射阿柏西普 8mg 治疗新生血管性年龄相关性黄斑变性(PULSAR):一项随机、双盲、非劣效性、3 期临床试验的 48 周结果。
Lancet. 2024 Mar 23;403(10432):1141-1152. doi: 10.1016/S0140-6736(24)00063-1. Epub 2024 Mar 7.
2
A New Generation of Gene Therapies as the Future of Wet AMD Treatment.新一代基因疗法作为湿性 AMD 治疗的未来。
Int J Mol Sci. 2024 Feb 17;25(4):2386. doi: 10.3390/ijms25042386.
3
Gold Carding Policies: Reducing the Barriers Between Payers and Providers.金卡政策:减少支付方与医疗服务提供方之间的障碍。
Neurol Clin Pract. 2024 Apr;14(2):e200256. doi: 10.1212/CPJ.0000000000200256. Epub 2024 Jan 10.
4
A primer on brand-name prescription drug reimbursement in the United States.美国名牌处方药报销概述。
J Manag Care Spec Pharm. 2024 Jan;30(1):99-106. doi: 10.18553/jmcp.2024.30.1.99.
5
Safety and efficacy of ixoberogene soroparvovec in neovascular age-related macular degeneration in the United States (OPTIC): a prospective, two-year, multicentre phase 1 study.在美国开展的关于ixoberogene soroparvovec治疗新生血管性年龄相关性黄斑变性的安全性和有效性研究(OPTIC):一项前瞻性、为期两年的多中心1期研究。
EClinicalMedicine. 2023 Dec 22;67:102394. doi: 10.1016/j.eclinm.2023.102394. eCollection 2024 Jan.
6
Treatment burden on patients receiving intravitreal anti-VEGF for wet age-related macular degeneration.接受抗血管内皮生长因子眼内注射治疗湿性年龄相关性黄斑变性患者的治疗负担。
Acta Ophthalmol. 2024 Jun;102(4):478-482. doi: 10.1111/aos.15783. Epub 2023 Oct 6.
7
Through the Eyes of Patients: Understanding Treatment Burden of Intravitreal Anti-VEGF Injections for nAMD Patients in Norway.透过患者视角:了解挪威湿性年龄相关性黄斑变性患者玻璃体内注射抗血管内皮生长因子的治疗负担
Clin Ophthalmol. 2023 May 25;17:1465-1474. doi: 10.2147/OPTH.S409103. eCollection 2023.
8
Treat-and-extend dosing of intravitreal anti-VEGF agents in neovascular age-related macular degeneration: a meta-analysis.抗血管内皮生长因子药物玻璃体腔内注射治疗新生血管性年龄相关性黄斑变性的按需治疗策略:一项荟萃分析。
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9
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10
Prevalence of Age-Related Macular Degeneration in the US in 2019.2019 年美国年龄相关性黄斑变性的患病率。
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利益相关者对成本、质量以及在湿性年龄相关性黄斑变性的管理式医疗决策中纳入患者意见的看法:来自 AMCP 市场洞察计划的研究结果。

Stakeholder insights on cost, quality, and incorporating patient voice in managed care decisions on neovascular (wet) age-related macular degeneration: Findings from the AMCP Market Insights program.

机构信息

Connected Content, Ltd., Boulder, CO.

University of Florida College of Pharmacy, Gainesville.

出版信息

J Manag Care Spec Pharm. 2024 Nov;30(11-a Suppl):S1-S9. doi: 10.18553/jmcp.2024.30.11-a.s1.

DOI:10.18553/jmcp.2024.30.11-a.s1
PMID:39475629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11529448/
Abstract

Wet age-related macular degeneration (AMD) is an acquired degeneration of the retina that can lead to central vision impairment. It is primarily treated with intravitreal injections of vascular endothelial growth factor inhibitors. Although vascular endothelial growth factor inhibitors can effectively prevent progression of vision loss in many patients, they require ongoing regular administration and are therefore associated with considerable treatment burden. To gain insights into the impact of wet AMD and its treatment, AMCP convened an expert panel of managed care stakeholders in April 2024 through its Market Insights program. Key issues related to wet AMD identified by participants included cost and affordability, provider-related considerations, biosimilar adoption, measuring and improving quality, and incorporating the patient voice. Suggested payer best practices related to these issues in wet AMD also emerged from the discussion.

摘要

湿性年龄相关性黄斑变性(AMD)是一种视网膜获得性变性,可导致中心视力损害。它主要通过玻璃体内注射血管内皮生长因子抑制剂进行治疗。尽管血管内皮生长因子抑制剂可以有效预防许多患者视力丧失的进展,但它们需要持续定期给药,因此与相当大的治疗负担相关。为了深入了解湿性 AMD 及其治疗的影响,AMCP 通过其市场洞察计划于 2024 年 4 月召集了一个管理式医疗利益相关者专家组。参与者确定的与湿性 AMD 相关的关键问题包括成本和负担能力、与提供者相关的考虑因素、生物类似药的采用、衡量和提高质量,以及纳入患者的意见。讨论还提出了与湿性 AMD 相关问题的支付方最佳实践建议。